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RATIONALE Obesity increases the risk and severity of sleep-disordered breathing. The degree to which excess body weight contributes to blood oxygen desaturation during hypopneic and apneic events has not been comprehensively characterized. OBJECTIVES To quantify the association between excess body weight and oxygen desaturation during sleep-disordered(More)
STUDY OBJECTIVES To evaluate the effect of respiratory scoring criteria on diagnosis and classification of sleep disordered breathing (SDB) in chronic heart failure (CHF). DESIGN Cross-sectional observational study. SETTING Heart failure and general cardiology clinics at two London hospitals. PATIENTS OR PARTICIPANTS One hundred eighty stable patients(More)
BACKGROUND Sleep-disordered breathing (SDB) is under diagnosed in chronic heart failure (CHF). Screening with simple monitors may increase detection of SDB in a cardiology setting. This study aimed to evaluate the accuracy of heart rate variability analysis and overnight pulse oximetry for diagnosis of SDB in patients with CHF. METHODS 180 patients with(More)
BACKGROUND Patent foramen ovale (PFO) may contribute to nocturnal desaturation in patients with obstructive sleep apnea (OSA), and the effect of PFO closure in OSA is unknown. Our study tested the hypotheses that: (1) patients with severe OSA have a higher prevalence of PFO compared with healthy control subjects, (2) patients with severe OSA with clinically(More)
The influence of pH, application technique, and chlorine-to-nitrogen weight ratio on the bactericidal activity of inorganic chloramine compounds was determined with stock and environmental strains of Escherichia coli, Salmonella spp., Pseudomonas aeruginosa, Klebsiella pneumoniae, and Enterobacter cloacae. The rate of inactivation increased from 1.5 to 2(More)
The interference of nitrogenous organic compounds on the bactericidal activity of chloramines w a ~ examined. The amino acid glycine (0.1-0.5 mg/L as nitrogen) was supplemented into water samples obtained from a finished water reservoir to artificially increase the levels of organic nitrogen. Inactivation rates of total count bacteria were markedly slower(More)
The increased prevalence of obstructive sleep apnea (OSA) in congestive heart failure (CHF) may be associated with rostral fluid shift. We investigated the effect of overnight rostral fluid shift on pharyngeal collapsibility (Pcrit), pharyngeal caliber (APmean), and apnea-hypopnea index (AHI) in CHF patients. Twenty-three optimally treated systolic CHF(More)
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