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BACKGROUND The prognostic implications of cognitive impairment in amyotrophic lateral sclerosis (ALS) are not established. OBJECTIVES To investigate the survival effect of the comorbid frontotemporal dementia (FTD) and to determine whether, in the absence of dementia, impairment in different cognitive domains affects outcome. METHODS A prospective(More)
The present study endeavored to calculate a conservative estimate of both incidence- and prevalence-based costs of nonepileptic attack disorder (NEAD) in Ireland by applying previously identified prevalence figures to Irish population figures. Variables related to the economic cost of NEAD were identified based on a retrospective chart review of patients(More)
  • P C Lekic, N Pender, C A G Mcculloch
  • 1997
There are wide variations of gene expression and strikingly different responses to extracellular signals among different fibroblast populations. This has prompted a large number of in vitro studies which suggest that fibroblasts are not homogeneous but instead comprise multiple subpopulations with extensive site-to-site and intra-site variations.(More)
Recent advances have led to an increased understanding of the Ca(2+)-signalling pathway leading to exocytosis in bovine adrenal chromaffin cells. Video-imaging studies have allowed the temporal and spatial aspects of the Ca2+ signal to be investigated in detail. Ca2+ entry at the plasma membrane appears to be crucial for the activation of exocytosis. Ca2+(More)
The aim of this investigation was to compare the repeatability of measuring enamel demineralization surrounding an orthodontic bracket using two techniques: computerized image analysis from digitally converted photographic slides and quantitative light-induced fluorescence (QLF). Fifteen human molars were halved and shaped to look like incisors. The teeth(More)
  • R Lehman, A Romuli, V Bakker, W J B Houston, N Pender, E Dresner +2 others
  • 2009
Early treatment of palatally erupting maxillary canines by extraction of the primary canines Sune Ericson and Juri Kurol 283 Histologic reactions in gingival and alveolar tissues during tooth movement in rabbits 309 An experimental investigation into the effect of dimensional change on the stiffness of double vertical incisor alignment loops I. D. Brown 319(More)
Both nicotinic stimulation and histamine are able to raise cytosolic free calcium concentration in the majority of cells in a population of bovine adrenal medullary chromaffin cells to comparable levels. Nevertheless, histamine induces much less catecholamine secretion than does nicotine. In order to test whether this is due to heterogeneity in the(More)
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