Neil Oxtoby

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We demonstrate the use of a probabilistic generative model to explore the biomarker changes occurring as Alzheimer's disease develops and progresses. We enhanced the recently introduced event-based model for use with a multi-modal sporadic disease data set. This allows us to determine the sequence in which Alzheimer's disease biomarkers become abnormal(More)
In this paper we propose a novel algorithm which leverages models of white matter fibre dispersion to improve tractography. Tractography methods exploit directional information from diffusion weighted magnetic resonance (DW-MR) imaging to infer connectivity between different brain regions. Most tractography methods use a single direction (e.g. the principal(More)
The event-based model constructs a discrete picture of disease progression from cross-sectional data sets, with each event corresponding to a new biomarker becoming abnormal. However, it relies on the assumption that all subjects follow a single event sequence. This is a major simplification for sporadic disease data sets, which are highly heterogeneous,(More)
We present a framework for simulating cross-sectional or longitudinal biomarker data sets from neurodegenerative disease cohorts that reflect the temporal evolution of the disease and population diversity. The simulation system provides a mechanism for evaluating the performance of data-driven models of disease progression, which bring together biomarker(More)
Tracking myriad (thousands of) interacting dust particle targets in a complex (dusty) plasma is considered. Multiple extended-Kalman-filter-based trackers were deployed on target subsets of various sizes, with track data fusion performed offline. Filter-based tracking was more accurate than particle tracking velocimetry, particularly for estimates of target(More)
We consider non-interacting multi-qubit systems as controllable probes of an environment of defects/impurities modelled as a composite spin-boson environment. The spin-boson environment consists of a small number of quantum-coherent two-level fluctuators (TLFs) damped by independent bosonic baths. A master equation of the Lindblad form is derived for the(More)
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