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Poor air quality is a global health issue, causing serious problems like asthma, cancer, and heart disease around the world. Earlier this decade, the World Health Organization estimated that three million people die each year from the effects of air pollution [6]. Unfortunately, while variations in air quality are significant, today's air quality monitors(More)
Poor air quality is a global health issue, causing serious problems like asthma, cancer, and heart disease around the world. Earlier this decade, the World Health Organization estimated that three million people die each year from the effects of air pollution [6]. Unfortunately, while variations in air quality are significant, today's air quality monitors(More)
Cellular behavior in response to stimulatory cues is governed by information encoded within a complex intracellular signaling network. An understanding of how phenotype is determined requires the distributed characterization of signaling processes (e.g., phosphorylation states and kinase activities) in parallel with measures of resulting cell function. We(More)
Although human epidermal growth factor receptor 2 (HER2) overexpression is implicated in tumor progression for a variety of cancer types, how it dysregulates signaling networks governing cell behavioral functions is poorly understood. To address this problem, we use quantitative mass spectrometry to analyze dynamic effects of HER2 overexpression on(More)
As sensing technologies become increasingly distributed and democ-ratized, citizens and novice users are becoming responsible for the kinds of data collection and analysis that have traditionally been the purview of professional scientists and analysts. Leveraging this citizen engagement effectively, however, requires not only tools for sensing and data(More)
Small-molecule kinase inhibitors often modulate signaling pathways other than the one targeted, whether by direct "off-target" effects or by indirect "pathway cross-talk" effects. The presence of either or both of these classes of complicating factors impedes the predictive understanding of kinase inhibitor consequences for cell phenotypic behaviors(More)
Digital fabrication has enabled massive creativity in hobbyist communities and professional product design. These emerging technologies excel at realizing an arbitrary shape or form; however these objects are often rigid and lack the feel desired by designers. We aim to enable physical haptic design in passive 3D printed objects. This paper identifies two(More)
BACKGROUND Ulnar collateral ligament reconstruction (UCLR) is commonly performed in Major League Baseball (MLB) pitchers, but little is known about the preoperative pitch type and velocity characteristics of pitchers who go on to undergo UCLR. HYPOTHESIS Pitchers who required UCLR have thrown a greater percentage of fastballs and have greater pitch(More)
Figure 1. Example objects created with HapticPrint. External and Internal tools allow users to easily add tactility, flexibility, and weight to objects. ABSTRACT Digital fabrication has enabled massive creativity in hobbyist communities and professional product design. These emerging technologies excel at realizing an arbitrary shape or form; however these(More)
Cellular behavior in response to stimulatory cues is governed by information encoded within a complex intracellular signaling network. An understanding of how phenotype is determined requires the distributed characterization of signaling processes (e.g., phosphorylation states and kinase activities) in parallel with measures of resulting cell function. We(More)