Neil K Archibald

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As a more complete picture of the clinical phenotype of Parkinson's disease emerges, non-motor symptoms have become increasingly studied. Prominent among these non-motor phenomena are mood disturbance, cognitive decline and dementia, sleep disorders, hyposmia and autonomic failure. In addition, visual symptoms are common, ranging from complaints of dry eyes(More)
Visual symptoms are common in PD and PD dementia and include difficulty reading, double vision, illusions, feelings of presence and passage, and complex visual hallucinations. Despite the established prognostic implications of complex visual hallucinations, the interaction between cognitive decline, visual impairment, and other visual symptoms remains(More)
Sweet's syndrome, or acute febrile neutrophilic dermatosis, is a multisystem, inflammatory disease characterised by tender skin lesions and neutrophilic infiltration of various organs, including the nervous system. A rare condition, neuro-Sweet's can present with a wide variety of neurological symptoms dependent on the region of the CNS affected. Here we(More)
Visuospatial dysfunction may play a crucial role in gait disturbance in Parkinson's disease (PD), in particular how visual exploration of the environment is integrated into gait control. In this study, we tested the hypothesis that people with PD would visually sample their environment less frequently than controls when walking under different levels of(More)
Parkinson's disease, typically thought of as a movement disorder, is increasingly recognized as causing cognitive impairment and dementia. Eye movement abnormalities are also described, including impairment of rapid eye movements (saccades) and the fixations interspersed between them. Such movements are under the influence of cortical and subcortical(More)
Parkinson disease (PD) is the second commonest neurodegenerative disorder in the UK with an increasing prevalence in our aging population. The clinical features of PD are varied with a variety of "motor" and "nonmotor" symptoms and the condition is best thought of as a multisystem neurodegenerative disorder rather than as a "pure" movement disorder.(More)
OBJECTIVES Visual hallucinations (VH) most commonly occur in eye disease (ED), Parkinson disease (PD), and Lewy body dementia (LBD). The phenomenology of VH is likely to carry important information about the brain areas within the visual system generating them. METHODS Data from five controlled cross-sectional VH studies (164 controls, 135 ED, 156 PD, 79(More)
BACKGROUND Although visuospatial deficits have been linked with freezing of gait (FOG) in Parkinson's disease (PD), the specific effects of dorsal and ventral visual pathway dysfunction on FOG is not well understood. METHOD We assessed visuospatial function in FOG using an angle discrimination test (dorsal visual pathway bias) and overlapping figure test(More)
Dopa responsive dystonia results from abnormalities in the dopamine synthesis pathway which produces an array of phenotypic presentations with equally numerous genotypes. First documented in children in 1971, the 'classic' phenotype is childhood onset, predominantly lower limb dystonia which gradually progresses to generalised dystonia. Other hallmarks of(More)
A 77-year-old man, with a long history of idiopathic Parkinson's disease, was reviewed in the movement disorder clinic of the James Cook University Hospital. He had first presented to the neurological services 17 years previously with an asymmetrical, progressive upper limb tremor and associated rigidity. He had an otherwise unremarkable medical history. He(More)
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