Neil John Glassford

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Choice of renal replacement therapy (RRT) modality may affect renal recovery after acute kidney injury (AKI). We sought to compare the rate of dialysis dependence among severe AKI survivors according to the choice of initial renal replacement therapy (RRT) modality applied [continuous (CRRT) or intermittent (IRRT)]. Systematic searches of peer-reviewed(More)
OBJECTIVES To assess the feasibility and safety of a conservative approach to oxygen therapy in mechanically ventilated ICU patients. DESIGN Pilot prospective before-and-after study. SETTING A 22-bed multidisciplinary ICU of a tertiary care hospital in Australia. PATIENTS A total of 105 adult (18 years old or older) patients required mechanical(More)
In a previous study, restricting intravenous chloride administration in ICU patients decreased the incidence of acute kidney injury (AKI). To test the robustness of this finding, we extended our observation period to 12 months. The study extension included a 1-year control period (18 August 2007 to 17 August 2008) and a 1-year intervention period (18(More)
Different molecular forms of urinary neutrophil gelatinase-associated lipocalin (NGAL) have recently been discovered. We aimed to explore the nature, source and discriminatory value of urinary NGAL in intensive care unit (ICU) patients. We simultaneously measured plasma NGAL (pNGAL), urinary NGAL (uNGAL), and estimated monomeric and homodimeric uNGAL(More)
PURPOSE Oxygen (O2) is the most common therapy in mechanically ventilated patients, but targets and dose are poorly understood. We aimed to describe current O2 administration and titration in such patients in an academic intensive care unit. MATERIALS AND METHODS In consecutive ventilated (>48 hours) patients we prospectively obtained fraction of inspired(More)
PURPOSE Monitoring of fluid balance (FB) can be achieved by subtracting recorded fluid output from input or by measuring changes in body weight (BW). The latter approach is difficult in the critically ill. Recently, hospital beds have become available with the ability to directly weigh patients in the intensive care unit (ICU) patients directly. We sought(More)
OBJECTIVES To review systematically data from randomized and nonrandomized studies of fluid bolus therapy in hospitalized children with septic shock. DATA SOURCES Medline, EMBASE, and Cochrane Central Register of Controlled Trials. STUDY SELECTION We searched for randomized controlled studies of fluid bolus therapy in children with severe sepsis. We(More)
PURPOSE OF REVIEW The role of fluid balance as an important contributor to patient morbidity and mortality in the peri-operative period is only now being understood. Numerous studies in disparate populations undergoing different surgeries suggest that. RECENT FINDINGS There is wide disparity in fluid administration regimen between speciality, country, and(More)
PURPOSE OF REVIEW Successful renal recovery is a key goal of patient management during acute kidney injury in critically ill patients. However, limited information exists to guide clinicians as to what interventions might either decrease or increase the likelihood of renal recovery and especially renal recovery to dialysis independence. The purpose of this(More)
OBJECTIVES To describe the self-reported practice of loop diuretic therapy (LDT) administration by intensivists in Australia and New Zealand and to ascertain the anticipated clinical and physiological effects of LDT for several common clinical indications. DESIGN Structured online questionnaire distributed to intensivists via the Australian and New(More)