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A Mechanism Linking Extra Centrosomes to Chromosomal Instability
Chromosomal instability (CIN) is a hallmark of many tumours and correlates with the presence of extra centrosomes. However, a direct mechanistic link between extra centrosomes and CIN has not been… Expand
DNA breaks and chromosome pulverization from errors in mitosis
The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of debate, in large part because of the lack of insight into underlying mechanisms. Here we identify a mechanism by… Expand
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.
Multiple centrosomes in tumor cells create the potential for multipolar divisions that can lead to aneuploidy and cell death. Nevertheless, many cancer cells successfully divide because of mechanisms… Expand
Efficient Mitosis in Human Cells Lacking Poleward Microtubule Flux
Chromosome segregation relies on the dynamic properties of spindle microtubules (MTs). Poleward MT flux contributes to spindle dynamics through the disassembly of MT minus ends at spindle poles… Expand
Tetraploidy, aneuploidy and cancer.
- Neil J Ganem, Z. Storchová, D. Pellman
- Biology, Medicine
- Current opinion in genetics & development
- 1 April 2007
Aneuploidy is one of the most obvious differences between normal and cancer cells. However, there remains debate over how aneuploid cells arise and whether or not they are a cause or consequence of… Expand
Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation
Genetically unstable tetraploid cells can promote tumorigenesis. Recent estimates suggest that ∼37% of human tumors have undergone a genome-doubling event during their development. This potentially… Expand
Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors
Cancer's alternative means to an end To stay alive and proliferating, tumor cells must maintain their telomeres: the DNA sequences at the ends of chromosomes. The majority accomplish this by… Expand
The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK
Although the microtubule-depolymerizing KinI motor Kif2a is abundantly expressed in neuronal cells, we now show it localizes to centrosomes and spindle poles during mitosis in cultured cells.… Expand
The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.
- A. Manning, Neil J Ganem, S. Bakhoum, M. Wagenbach, L. Wordeman, D. Compton
- Biology, Medicine
- Molecular biology of the cell
- 1 August 2007
The human genome has three unique genes coding for kinesin-13 proteins called Kif2a, Kif2b, and MCAK (Kif2c). Kif2a and MCAK have documented roles in mitosis, but the function of Kif2b has not been… Expand
Linking abnormal mitosis to the acquisition of DNA damage
Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct and indirect… Expand