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The presentation, management, and outcome of three cases of femoral artery mycotic aneurysm in pregnancy are described. All resulted from illicit intravenous drug use. While the literature dealing with drug abuse in pregnancy is large, this specific problem has received little attention. Comparison of these cases to a large reported series of nonpregnant(More)
Mitomycin-C (MMC) is an alkylating agent which has shown significant activity in gynecologic cancers, both in vivo and in vitro. We determined the delivery of MMC to target tissue by comparing plasma and tumor tissue concentrations of MMC as measured by high-performance liquid chromatography (HPLC) in five patients with cervical cancer. In a companion(More)
Nineteen patients with poor prognosis squamous cell cancer of the cervix were treated with concurrent radiation therapy (RT) and chemotherapy between February 1986 and July 1988. Treatment consisted of intravenous Mitomycin C 10 mg/m2 on days 1 and 43 and cis-platinum 50 mg/m2 on days 1, 22, and 43. All patients received external RT (5,000 cGy in 28(More)
From December 1986 through July 1987, forty-one Groshong catheters were inserted in 38 patients with invasive gynecologic cancer for a cumulative total of 4170 days of patient use. (mean catheter indwelling time: 93 days; range: 3-300 days). A supraclavicular approach was used to cannulate the brachiocephalic vein in 31 patients. In 6 patients, the(More)
Although cancer complicates pregnancy infrequently, its occurrence jeopardizes maternal and fetal well-being. Treatment with chemotherapeutic agents may adversely affect rapidly dividing fetal tissue, while physiologic changes in pregnancy may alter maternal drug disposition. Previous work on placental transfer and pregnancy-specific kinetics of(More)
ion generalising the problem, identifying the essentials of the solution decomposition breaking the problem and solutions down into simpler smaller parts elaboration the detailed design decision making identification of and selection between alternative strategies. It points out that the safety requirements i.e. what the system must and must not do in order(More)
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