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Ecstasy: are animal data consistent between species and can they translate to humans?

• Neil Easton, Charles Alexander Marsden
• Journal of psychopharmacology
• 2006

The number of 3,4-methylenedioxymethamphetamine (ecstasy or MDMA) animal research articles is rapidly increasing and yet studies which place emphasis on the clinical significance are limited due to a… (More)

Effects of amphetamine isomers, methylphenidate and atomoxetine on synaptosomal and synaptic vesicle accumulation and release of dopamine and noradrenaline in vitro in the rat brain

• Neil Easton, Carolyn Steward, Fiona Marshall, Kevin C. F. Fone, Charles Alexandar Marsden
• Neuropharmacology
• 2007

D- and L-amphetamine sulphate isomers, methylphenidate and atomoxetine, are effective treatments for attention-deficit hyperactivity disorder (ADHD). This study provides a detailed comparison of… (More)

Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists.

• Steven P. Vickers, Neil Easton, +4 authors Guy A. Kennett
• Pharmacology, biochemistry, and behavior
• 2001

The pharmacology of several commonly described 5-hydroxytryptamine (5-HT)(2C) receptor agonists was investigated in vivo and in vitro at rat 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptors. The 5-HT(2C)… (More)

Oral administration of the 5-HT2C receptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia

• Steven P. Vickers, Neil Easton, +4 authors Guy A. Kennett
• Psychopharmacology
• 2003

Rationale. The 5-HT2C receptor subtype has been implicated extensively in the regulation of ingestive behaviour. Objective. To assess whether chronic administration of the preferential 5-HT2C… (More)

Differential effects of the d- and l- isomers of amphetamine on pharmacological MRI BOLD contrast in the rat

• Neil Easton, Fiona H Marshall, Kevin C. F. Fone, Charles Alexander Marsden
• Psychopharmacology
• 2007

The d- and l-amphetamine sulphate isomers are used in the formulation of Adderall XR®, which is effective in the treatment of attention-deficit hyperactivity disorder (ADHD). The effects of these… (More)

Individualized care: is it possible to plan and carry out?

• Karen Waters, Neil Easton
• Journal of advanced nursing
• 1999

The purpose of the study reported in this paper was to assess the reality of attempting to deliver individualized nursing care. An ethnographic case study research design was used on a nursing… (More)

Synthesis, in vitro formation, and behavioural effects of glutathione regioisomers of alpha-methyldopamine with relevance to MDA and MDMA (ecstasy)

• Neil Easton, J. Fry, Esther O’Shea, Adam Watkins, Charles Alexander Marsden
• Brain Research
• 2003

Administration of 3,4-methylenedioxymethamphetamine (MDMA) or 3,4-methylenedioxyamphetamine (MDA) to rats produces serotonergic nerve terminal degeneration. However, they are not neurotoxic when… (More)

Mapping the central effects of methylphenidate in the rat using pharmacological MRI BOLD contrast

• Neil Easton, Fiona H Marshall, Charles Alexander Marsden, Kevin C. F. Fone
• Neuropharmacology
• 2009

Methylphenidate (Ritalin) is a selective dopamine reuptake inhibitor and an effective treatment for attention deficit hyperactivity disorder (ADHD) however the anatomical foci and neuronal circuits… (More)

Protection against 3,4-methylenedioxymethamphetamine-induced neurodegeneration produced by glutathione depletion in rats is mediated by attenuation of hyperthermia.

• Esther O'shea, Neil Easton, Jeffrey R. Fry, Alfred Richard Green, Charles Alexander Marsden
• Journal of neurochemistry
• 2002

3,4-Methylenedioxymethamphetamine (MDMA) administration produces neurotoxic degeneration of serotonin terminals in rat brain. These effects occur only after systemic administration and not after… (More)

Guanfacine produces differential effects in frontal cortex compared with striatum: assessed by phMRI BOLD contrast

• Neil Easton, Yasmene B. Shah, Fiona H Marshall, Kevin C. F. Fone, Charles Alexander Marsden
• Psychopharmacology
• 2006

Guanfacine (an alpha-2A adrenoreceptor agonist) is a drug of benefit in the treatment of attention deficit hyperactivity disorder (ADHD) (Taylor FB, Russo J, J Clin Psychopharmacol 21:223–228, 2001).… (More)

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