Neil E. Wilson

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The present article reports an experiment on the effects of baclofen (0, 0.5, 1.0, and 2.0 mg/kg) on punished drinking in rats and the modification of these by delta-amino-n-valeric acid (DANVA) (0 and 10.0 mg/kg). Baclofen significantly enhanced punished drinking and this increase was abolished by DANVA, which had no intrinsic anxiogenic activity. It is(More)
Neurohypophysial peptides were applied by superfusion to rat hippocampal slices. The peptides, arginine vasopressin, lysine vasopressin, arginine vasotocin and oxytocin, increased the activity of 88% of spontaneously active cells in the CA1 region and induced firing in many neurones that were not spontaneously active. The peptide sensitive cells appeared to(More)
The application of compressed sensing is demonstrated in a recently implemented four-dimensional echo-planar based J-resolved spectroscopic imaging sequence combining two spatial and two spectral dimensions. The echo-planar readout simultaneously acquires one spectral and one spatial dimension. Therefore, the compressed sensing undersampling is performed(More)
Hepatic encephalopathy (HE) is normally diagnosed by neuropsychological (NP) tests. The goals of this study were to quantify cerebral metabolites, separate glutamate (Glu) from glutamine (Gln) in patients with minimal hepatic encephalopathy (MHE) as well as healthy subjects using the prior-knowledge fitting (ProFit) algorithm on data acquired by(More)
An alternative to the standard echo-planar spectroscopic imaging technique is presented, spectroscopic imaging using concentrically circular echo-planar trajectories (SI-CONCEPT). In contrast to the conventional chemical shift imaging data, the sampled data from each set of concentric rings were regridded into Cartesian space. Usage of concentric k-space(More)
Immunocytochemical studies have demonstrated that nerve fibres containing immunoreactive vasopressin project to many areas of the central nervous system. In the present investigation, the presence of immunoreactive arginine vasopressin (IR-AVP) in the hippocampus of Wistar rats was confirmed by radioimmunoassay. The vasopressin content of the dorsal(More)
PURPOSE To implement an accelerated five-dimensional (5D) echo-planar J-resolved spectroscopic imaging sequence combining 3 spatial and 2 spectral encoding dimensions and to apply the sequence in human brain. METHODS An echo planar readout was used to acquire a single spatial and a single spectral dimension during one readout. Nonuniform sampling was(More)
Several different pathologies, including many neurodegenerative disorders, affect the energy metabolism of the brain. Glutamate, a neurotransmitter in the brain, can be used as a biomarker to monitor these metabolic processes. One method that is capable of quantifying glutamate concentration reliably in several regions of the brain is TE-averaged (1) H(More)
PURPOSE To implement a 5D (three spatial + two spectral) correlated spectroscopic imaging sequence for application to human calf. THEORY AND METHODS Nonuniform sampling was applied across the two phase encoded dimensions and the indirect spectral dimension of an echo planar-correlated spectroscopic imaging sequence. Reconstruction was applied that(More)