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A semi-automatic method to measure and quantify geometrical and topological properties of continuous vascular trees in clinical fundus images is described. Measurements are made from binary images obtained with a previously described segmentation process. The skeletons of the segmented trees are produced by thinning,ff branch and crossing points are(More)
Spironolactone is recommended as fourth-line therapy for essential hypertension despite few supporting data for this indication. We evaluated the effect among 1411 participants in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm who received spironolactone mainly as a fourth-line antihypertensive agent for uncontrolled blood(More)
A computerised system is presented for the automatic quantification of blood vessel topography in retinal images. This system utilises digital image processing techniques to provide more reliable and comprehensive information for the retinal vascular network. It applies strategies and algorithms for measuring vascular trees and includes methods for locating(More)
BACKGROUND AND PURPOSE The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) showed that blood pressure lowering reduced stroke risk in patients with a history of cerebrovascular events. Here, we report the consistency of treatment effects across different stroke subtypes and among major clinical subgroups. METHODS PROGRESS was a(More)
This paper presents travel time geoacoustic inversion of broadband data collected on a vertical line array at short range of 230 m during the Shallow Water 2006 experiments. A ray-tracing method combined with a hybrid optimization algorithm that utilizes differential evolution and downhill simplex was used for the inversion of sediment properties. The ocean(More)
BACKGROUND This programme of overviews of randomised trials was established to investigate the effects of angiotensin-converting-enzyme (ACE) inhibitors, calcium antagonists, and other blood-pressure-lowering drugs on mortality and major cardiovascular morbidity in several populations of patients. We did separate overviews of trials comparing active(More)
Arterial diameters at branch points are believed to conform to design principles that optimize circulatory efficiency and maintain constant shear stress across arterial networks. The objective of this study was to examine whether optimality at bifurcations is affected in individuals with atherosclerosis. Retinal images were analysed in normotensive men with(More)
This paper describes geoacoustic inversion of low frequency air gun data acquired during an experiment on the New Jersey shelf. Hybrid optimization and Bayesian inversion techniques based on matched field processing were applied to multiple shots from three air gun data sets recorded by a vertical line array in a long-range shallow water geometry. For the(More)
This paper presents results for matched field Bayesian geoacoustic inversion of multitonal continuous wave data collected on the New Jersey continental shelf. To account for effects of significant spatial and temporal variation of the water column sound speed, the sound speed profile was represented by empirical orthogonal functions. Data error information(More)
BACKGROUND AND PURPOSE Mean platelet volume (MPV) is positively associated with measures of platelet activity and may be a useful indicator of the risk of vascular events in a variety of patient groups. METHODS The association of MPV with the risk of stroke was assessed in the Perindopril Protection Against Recurrent Stroke Study (PROGRESS). All(More)