Neil C. Mitchell

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As a step toward exploring a targeted metabolomics approach to personalized warfarin (Coumadin) therapy, we developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method capable of quantifying specific enantiomeric (R and S) contributions of warfarin (WAR) and the corresponding hydroxywarfarins (OH-WAR) and glucuronides (-GLUC) generated by(More)
Our understanding of human phase II metabolic pathways which facilitate detoxification and excretion of warfarin (Coumadin) is limited. The goal of this study was to test the hypothesis that there are specific human hepatic and extrahepatic UDP-glucuronosyltransferase (UGT) isozymes, which are responsible for conjugating warfarin and hydroxylated(More)
[1] Bathymetry data collected with a multibeam echo sounder around Pico Island, Azores (Portugal), reveal a remarkable series of lava flows on the island's shelf with a variety of pristine structures that suggest how lava behaves on entering water. Many flows are dendritic in plan view, some with channels and tumuli. Dendritic geometries are interpreted to(More)
Much progress has been made in the UK in characterizing the internal structures of major physiographic features in the oceans and in developing understanding of the geological processes that have created or shaped them. UK researchers have authored articles of high impact in all areas described here. In contrast to terrestrial geoscience, however, there(More)
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