Neil Benson

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It is commonly the case in biochemical modelling that we have knowledge of the qualitative 'structure' of a model and some measurements of the time series of the variables of interest (concentrations and fluxes), but little or no knowledge of the model's parameters. This is, then, a system identification problem, that is commonly addressed by running a(More)
Contemporary small-molecule drug discovery frequently involves the screening of large compound files as a core activity. Subsequently cost, speed, and safety become critical issues. In order to meet this need, numerous technologies have been developed to allow mix and measure approaches, facilitate miniaturization, and to increase speed and to minimize the(More)
At 80, ISI and The Scientist founder Eugene Garfield isn't quite finished improving information analysis When he was a boy, Eugene Garfield lived across the street from a branch of the New York Public Library. There, he spent hours wandering through the stacks, scanning the titles of all the books on the shelves. "I had to get special permission, because(More)
Celiac disease (CD) is an autoimmune disorder that occurs in genetically predisposed people and is caused by a reaction to the gluten protein found in wheat, which leads to intestinal villous atrophy. Currently there is no drug for treatment of CD. The only known treatment is lifelong gluten-free diet. The main aim of this work is to develop a mathematical(More)
Parameter estimation is a hard, important and usually underdetermined problem. We introduce the constraint that the estimated parameters should be as close as possible to stated values in a way that is both deterministic and very effective. Please check this proof carefully. Our staff will not read it in detail after you have returned it. Translation errors(More)
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