Neil Alexander Macintyre

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BACKGROUND This joint statement is based on the previous statements from the American Thoracic Society (ATS) and the European Respiratory Society (ERS), and much of the material was taken from these statements [1, 2]. It has been updated according to new scientific insights and revised to reflect consensus opinions of both of these societies. This document(More)
c BACKGROUND In preparing the joint statements on lung function testing for the American Thoracic Society (ATS) and the European Respiratory Society (ERS), it was agreed by the working party that the format of the statements should be modified so that they were easier to use by both technical and clinical staff. This statement contains details about(More)
c BACKGROUND AND PURPOSE Inspired and expired lung volumes measured by spirometry are useful for detecting, characterising and quantifying the severity of lung disease. Measurements of absolute lung volumes, residual volume (RV), functional residual capacity (FRC) and total lung capacity (TLC) are technically more challenging, which limits their use in(More)
Lawsonia intracellularis is an obligate intracellular bacterium, responsible for the disease complex known as proliferative enteropathy (PE). L. intracellularis is associated with intestinal crypt epithelial cell proliferation but the mechanisms responsible are yet to be defined. Microarray analysis was used to investigate the host-pathogen interaction in(More)
Laminitis is a common debilitating disease in horses that involves painful disruption of the lamellar dermo-epidermal junction within the hoof. This condition is often refractory to conventional anti-inflammatory analgesia and results in unremitting pain, which in severe cases requires euthanasia. The mechanisms underlying pain in laminitis were(More)
Data Structure Curriculum (DSC) has abstract and dynamic features and it is difficult for learners to gain a full comprehension. According to its abstract features, related algorithms cases should be visualized in order to help learners more easily learn. And according to its dynamic feature, Imagery Training can be introduced into the method of(More)
Due to growing interest in management of central airway obstruction, rigid bronchoscopy is undergoing a resurgence in popularity among pulmonologists. Performing rigid bronchoscopy requires use of deep sedation or general anesthesia to achieve adequate patient comfort, whereas maintaining oxygenation and ventilation via an uncuffed and often open rigid(More)
The expression patterns of secreted (MUC2 and MUC5AC) and membrane-tethered (MUC1, MUC4, MUC12 and MUC13) mucins were monitored in healthy pigs and pigs challenged orally with Lawsonia intracellularis. These results showed that the regulation of mucin gene expression is distinctive along the GI tract of the healthy pig, and may reflect an association(More)