Neil A. Zakai

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Measurements of erythrocytes within the blood are important clinical traits and can indicate various hematological disorders. We report here genome-wide association studies (GWAS) for six erythrocyte traits, including hemoglobin concentration (Hb), hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular(More)
CONTEXT A triple-marker approach for chronic kidney disease (CKD) evaluation has not been well studied. OBJECTIVE To evaluate whether combining creatinine, cystatin C, and urine albumin-to-creatinine ratio (ACR) would improve identification of risks associated with CKD compared with creatinine alone. DESIGN, SETTING, AND PARTICIPANTS Prospective cohort(More)
BACKGROUND Poor lifestyle behaviors, including suboptimal diet, physical inactivity, and tobacco use, are leading causes of preventable diseases globally. Although even modest population shifts in risk substantially alter health outcomes, the optimal population-level approaches to improve lifestyle are not well established. METHODS AND RESULTS For this(More)
Genome-wide association studies (GWAS) have identified 36 loci associated with body mass index (BMI), predominantly in populations of European ancestry. We conducted a meta-analysis to examine the association of >3.2 million SNPs with BMI in 39,144 men and women of African ancestry and followed up the most significant associations in an additional 32,268(More)
White blood cell (WBC) count is a common clinical measure from complete blood count assays, and it varies widely among healthy individuals. Total WBC count and its constituent subtypes have been shown to be moderately heritable, with the heritability estimates varying across cell types. We studied 19,509 subjects from seven cohorts in a discovery analysis,(More)
BACKGROUND Anemia is viewed as a negative prognostic factor in the elderly population; its independent impact on survival is unclear. METHODS Baseline hemoglobin quintiles and anemia, as defined by the World Health Organization criteria, were assessed in relation to mortality in the Cardiovascular Health Study, a prospective cohort study with 11.2 years(More)
BACKGROUND Albuminuria and estimated glomerular filtration rate (eGFR) are each associated with increased risk of cognitive impairment, but their joint association is unknown. STUDY DESIGN Prospective cohort study. SETTING & PARTICIPANTS A US national sample of 19,399 adults without cognitive impairment at baseline participating in the REGARDS (Reasons(More)
Glenn N. Levine, MD, FAHA, Chair; Anthony V. D’Amico, MD, PhD; Peter Berger, MD, FAHA; Peter E. Clark, MD; Robert H. Eckel, MD, FAHA; Nancy L. Keating, MD, MPH; Richard V. Milani, MD, FAHA; Arthur I. Sagalowsky, MD; Matthew R. Smith, MD, PhD; Neil Zakai, MD; on behalf of the American Heart Association Council on Clinical Cardiology and Council on(More)
BACKGROUND Numerous case-control studies have reported higher prevalence of non-O blood type among venous thromboembolism (VTE) patients than controls, but potential mechanisms or effect modifiers for the association are not fully established. PATIENTS/METHODS Using a nested case-control design combining the Atherosclerosis Risk in Communities and the(More)
BACKGROUND There are few studies of inflammation and hemostasis biomarkers and cardiovascular disease risk (CVD) in older adults. OBJECTIVES To assess multiple biomarkers simultaneously and in combinations for CVD risk assessment in older individuals. PATIENTS/METHODS Thirteen biomarkers, interleukin-6 (IL-6), C-reactive protein (CRP), D-dimer,(More)