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BACKGROUND The literature describes contradictory data regarding the onset of the baroreflex reduction in spontaneously hypertensive rats. OBJECTIVE This investigation was undertaken to evaluate the baroreflex function in 13-week-old spontaneously hypertensive rats. METHODS Male Wistar Kyoto (n=15) and spontaneously hypertensive rats (n=15) aged 13(More)
PURPOSE To evaluate the myocardial protective effect of enalaprilat in rats submitted to stress by cold. METHODS Fifteen adults, male rats were studied. They were allocated into four groups: group A received unrestricted diet + intraperitoneal (IP) diluent; group B: unrestricted diet + IP enalaprilat 1.0 mg/kg; group C: high salt diet (HD) for seven days(More)
Although echocardiography has been used in rats, few studies have determined its efficacy for estimating myocardial infarct size. Our objective was to estimate the myocardial infarct size, and to evaluate anatomic and functional variables of the left ventricle. Myocardial infarction was produced in 43 female Wistar rats by ligature of the left coronary(More)
This study aims to determine whether a relation exists between ischemia/reperfusion and myocardial B-type natriuretic peptide (BNP) mRNA expression independent of variations in intracavitary diastolic volume and consequently, of cardiomyocyte stretching. Twenty-three rats were subjected to the following conditions: control (C), 15 min of ischemia (I15), or(More)
AIM The effectiveness of a water-based exercise (WE) program and a walking on land (WL) program was evaluated in older women (aged 62-65 years). METHODS Fifty healthy sedentary women were randomly assigned to sedentary (S), WE and WL groups. The two groups were exercised for 12 weeks at 70% of the age-predicted maximum heart rate (HR). The subjects were(More)
INTRODUCTION Total body induced hypothermia and myocardial cooling are effective methods regarding myocardial protection during heart surgery and ischemia. It is described in previous studies that extreme low temperature exposure causes mitochondrial cristae and myofilament disarrangement in cardiomyocytes, however, no investigation has analyzed the effects(More)
OBJECTIVE The study was designed to evaluate the effects of strength training (ST) on the bone mineral density (BMD) of postmenopausal women without hormone replacement therapy. METHOD Subjects were randomized into untrained (UN) or trained (TR) groups. The TR group exercised three ST sessions per week for 24 weeks, and body composition, muscular(More)
OBJECTIVE This study aimed to investigate whether previous exercise training could prevent or attenuate acute cardiac alterations after myocardial infarction. METHODS Female rats were submitted to swim training (1 h/day; 5 days/week) or allowed to remain sedentary for 8 weeks. Afterwards, they were randomly assigned to left coronary artery occlusion or(More)
BACKGROUND The immediate effects of surgical reduction of left ventricle cavity on cardiac mechanics have not been well defined. METHODS Cardiac mechanics were analyzed before and after myocardial infarction scar plication in 11 isolated infarcted rat hearts. RESULTS Despite a decrease in myocardial stiffness, an increase in chamber stiffness was noted(More)
OBJECTIVE To assess fluoxetine effects on mitochondrial structure of the right ventricle in rats exposed to cold stress. METHODS The experimental study procedures were performed in 250-300g male EPM-Wistar rats. Rats (n=40) were divided into four groups: 1) Control group (CON); 2) Fluoxetine (FLU); 3) Induced hypothermia (IH) and; 4) Induced hypothermia(More)