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Due to next-generation sequence technologies, sequencing of bacterial genomes is no longer one of the main bottlenecks in bacterial research and the number of new genomes deposited in public databases continues to increase at an accelerating rate. Among these new genomes, several belong to the same species and were generated for pan-genomic studies. A(More)
Vibrio cholerae is the causal organism of the cholera epidemic, which is mostly prevalent in developing and underdeveloped countries. However, incidences of cholera in developed countries are also alarming. Because of the emergence of new drug-resistant strains, even though several generic drugs and vaccines have been developed over time, Vibrio infections(More)
UNLABELLED miRNAs regulate post transcriptional gene expression by targeting multiple mRNAs and hence can modulate multiple signalling pathways, biological processes, and patho-physiologies. Therefore, understanding of miRNA regulatory networks is essential in order to modulate the functions of a miRNA. The focus of several existing databases is to provide(More)
Exploring miRNA-disease interactions is critical to identify the impact of a disease on other diseases. Mapping this problem to a graph theoretical concept offers a unique perspective to study unseen relationships among diseases. In our work, maximum weighted matching has been used after mapping the miRNA-disease associations as a bipartite graph. We also(More)
Inositol monophosphate plays an important role in treatment of bipolar disorders. Analogues with deleted or substituted 6-OH group and 1-phosphate group produce good inhibitors of Inositol Monophosphatase (IMPase) enzyme. Twenty two analogues displaying variable inhibition of IMPase were subjected to quantitative structure activity relationship analysis.(More)
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