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Patients with early age-of-onset Alzheimer's disease show more rapid progression, more generalized cognitive deficits and greater cortical atrophy and hypometabolism compared to late-onset patients at a similar disease stage. The biological mechanisms that underlie these differences are not well understood. The purpose of this study was to examine in vivo(More)
Genetically hard-wired neural mechanisms must enforce behavioral reproductive isolation because interspecies courtship is rare even in sexually naïve animals of most species. We find that the chemoreceptor Gr32a inhibits male D. melanogaster from courting diverse fruit fly species. Gr32a recognizes nonvolatile aversive cues present on these reproductively(More)
Systems from smartphones to supercomputers are increasingly heterogeneous, being composed of both CPUs and GPUs. To maximize cost and energy efficiency, these systems will increasingly use globally-addressable heterogeneous memory systems, making choices about memory page placement critical to performance. In this work we show that current page placement(More)
—Compute requirements are increasing rapidly in systems ranging from mobile devices to servers. These, often massively parallel architectures, put increasing requirements on memory bandwidth and latency. The memory system greatly impacts both system performance and power, and it is key to capture the complex behaviour of the DRAM controller when evaluating(More)
—Historically, GPU-based HPC applications have had a substantial memory bandwidth advantage over CPU-based workloads due to using GDDR rather than DDR memory. However , past GPUs required a restricted programming model where application data was allocated up front and explicitly copied into GPU memory before launching a GPU kernel by the programmer.(More)
BACKGROUND Previous studies have demonstrated alterations in the peripheral cholinergic system in Alzheimer's disease (AD), though results have been inconsistent and not linked to in vivo biomarkers of pathology. We examined the relationship between amyloid-beta (Aβ) plaques and plasma cholinesterase activity in a heterogeneous dementia population. (More)
Crouzon syndrome, also called craniofacial dysostosis, is an autosomal dominant disorder with complete penetrance and variable expressivity. Described by a French neurosurgeon in 1912, it is a rare genetic disorder characterized by premature closure of cranial sutures, midfacial hypoplasia, and orbital defects. Here, we report a case of this rare entity.(More)
BACKGROUND & OBJECTIVES Peak bone mass, a major determinant of osteoporosis is influenced by genetic, nutritional, lifestyle and hormonal factors. This study was designed to evaluate the impact of sports training on dietary intake and bone mineral and metabolic parameters in young healthy Indian females. METHODS Healthy female college going students(More)