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Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death.
Preclinical pharmacokinetics and bioavailability of noscapine, a tubulin-binding anticancer agent
- R. Aneja, Neerupma Dhiman, H. Joshi
- Medicine, BiologyCancer Chemotherapy and Pharmacology
- 7 February 2007
A simple, sensitive, quantitative, selective, and less time-consuming high-performance liquid chromatography (HPLC) method for determination of noscapine and to study its pharmacokinetics in mice models is developed.
Long-circulating poly(ethylene glycol)-grafted gelatin nanoparticles customized for intracellular delivery of noscapine: preparation, in-vitro characterization, structure elucidation,…
- J. Madan, Neerupma Dhiman, S. Sardana, R. Aneja, R. Chandra, A. Katyal
- BiologyAnti-Cancer Drugs
- 1 July 2011
Noscapine-loaded poly(ethylene glycol)-grafted gelatin nanoparticles can be developed as a promising therapeutic agent for the management of breast cancer.
PHARMACOGNOSTIC AND PRELIMINARY PHYTOCHEMICAL INVESTIGATION OF WHOLE PLANT EXTRACT OF CUSCUTA REFLEXA GROWING ON DIFFERENT HOST PLANTS
The aim of the present study was focused on the pharmacognostical and phytochemical properties, which would like to facilitate quick identification and selection of the drug from various adulterates.
DETERMINATION OF SUN PROTECTION FACTOR IN DIFFERENT EXTRACT OF EULALIOPSIS BINATA
Sunscreens aid enhancing the body's natural beauty and defence system, which protect the skin against ageing and Ultra-Violet radiation. The present study involves the evaluation of sun protection…
Coronavirus (SARS-CoV-2): Preventions, keys to diagnosis and treatment of SARS-CoV-2
- K. Patel, J. Rathi, Karun Raghuvanshi, Neerupma Dhiman
- Medicine, BiologyIberoamerican Journal of Medicine
- 18 March 2020
The basic life cycle and replication of the well-studied coronav virus, mouse hepatitis virus (MHV), identifying the unique characteristics of coronavirus biology and highlighting critical points where research has made significant advances, and which might represent targets for antivirals or vaccines are discussed.
Inclusion complexes of noscapine in β-cyclodextrin offer better solubility and improved pharmacokinetics
- J. Madan, Neerupma Dhiman, A. Katyal
- Biology, ChemistryCancer Chemotherapy and Pharmacology
- 1 February 2010
These studies propose for the first time a stable NOS–β-CD inclusion complex as an effective approach to enhance the solubility and bioavailability of NOS for anticancer therapy.
Non‐toxic melanoma therapy by a novel tubulin‐binding agent
It is shown that EM011 modulates microtubule dynamics at concentrations that do not alter the total polymer mass of tubulin, and is non‐toxic to normal tissues and most importantly, does not cause any immunosuppression and neurotoxicity.
Recent advances on Berberis aristata emphasizing berberine alkaloid including phytochemistry, pharmacology and drug delivery system
Lipid Nanoparticles as Carriers for Bioactive Delivery
- Neerupma Dhiman, R. Awasthi, Bhupesh Sharma, H. Kharkwal, G. Kulkarni
- Biology, ChemistryFrontiers in Chemistry
- 23 April 2021
A bird's eye view on various aspects of lipid nanoparticles as carriers of bioactive molecules that is, synthesis, characterization, advantage, disadvantage, toxicity, and application in the medical field are presented.