Neelima Tangirala

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Activation of oncogenes or inactivation of tumor suppressors in urothelium is considered critical for development of urothelial cancer. Here we report cloning of the urothelium-specific promoter uroplakin-II (UPK II) and generation of transgenic mice in which expression of SV40 large T antigen is driven by UPK II promoter. Inactivation of tumor suppressor(More)
Activation of oncogenes or inactivation of tumor suppressors in urothelium is considered critical for development of urothelial cancer. Here we report cloning of the urothelium specific promoter uroplakin-II (UPKII) and generation of transgenic mice in which expression of SV40 large T antigen is driven by UPKII promoter. Inactivation of tumor suppressor p53(More)
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