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Development of positron emission tomography β-amyloid plaque imaging agents.
For 100 years, β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) have been recognized as the neuropathological hallmarks of Alzheimer's disease (AD), and their presence or absence could onlyExpand
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Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials
Objective: To evaluate the effects of bapineuzumab on brain β-amyloid (Aβ) burden using 11C-Pittsburgh compound B (11C-PiB)-PET. Methods: Two phase 3 clinical trials, 1 each in apolipoprotein APOE ε4Expand
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A [polycation:heparin] complex releases growth factors with enhanced bioactivity.
Growth factors are potent molecules that regulate cell functions including survival, self renewal, differentiation and proliferation. High-efficacy delivery of growth factors will be a powerful toolExpand
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Controlled Release of IGF-1 and HGF from a Biodegradable Polyurethane Scaffold
ABSTRACTPurposeBiodegradable elastomers, which can possess favorable mechanical properties and degradation rates for soft tissue engineering applications, are more recently being explored as depotsExpand
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Utility of 3'-[(18)F]fluoro-3'-deoxythymidine as a PET tracer to monitor response to gene therapy in a xenograft model of head and neck carcinoma.
Noninvasive imaging methodologies are needed to assess treatment responses to novel molecular targeting approaches for the treatment of squamous cell carcinoma of the head and neck (SCCHN). ComputerExpand
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Anti-Amyloid Effects of Small Molecule Aβ-Binding Agents in PS1/APP Mice.
AIMS: One promising approach for treatment of Alzheimer's disease (AD) is use of anti-amyloid therapies, based on the hypothesis that increases in amyloid-beta (Aβ) deposits in brain are a majorExpand
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Cardiac Targeting Peptide, a Novel Cardiac Vector: Studies in Bio-Distribution, Imaging Application, and Mechanism of Transduction
Our previous work identified a 12-amino acid peptide that targets the heart, termed cardiac targeting peptide (CTP). We now quantitatively assess the bio-distribution of CTP, show a clinicalExpand
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Modeling analysis of the CB1 PET tracer [11C]OMAR in rhesus monkeys and humans
Methods: Three rhesus monkeys underwent a total of 20 scans on the Focus220. PET data were acquired for 120 min after a bolus injection of 4.2±0.6 mCi [C]OMAR. In 6 self-blocking scans, unlabeledExpand
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