Neale S. Mason
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Development of positron emission tomography β-amyloid plaque imaging agents.
For 100 years, β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) have been recognized as the neuropathological hallmarks of Alzheimer's disease (AD), and their presence or absence could only… Expand
Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials
Objective: To evaluate the effects of bapineuzumab on brain β-amyloid (Aβ) burden using 11C-Pittsburgh compound B (11C-PiB)-PET. Methods: Two phase 3 clinical trials, 1 each in apolipoprotein APOE ε4… Expand
A [polycation:heparin] complex releases growth factors with enhanced bioactivity.
- Hunghao Chu, N. Johnson, N. S. Mason, Y. Wang
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 10 March 2011
Growth factors are potent molecules that regulate cell functions including survival, self renewal, differentiation and proliferation. High-efficacy delivery of growth factors will be a powerful tool… Expand
Controlled Release of IGF-1 and HGF from a Biodegradable Polyurethane Scaffold
- D. Nelson, P. Baraniak, Z. Ma, J. Guan, N. S. Mason, W. Wagner
- Chemistry, Medicine
- Pharmaceutical Research
- 23 February 2011
ABSTRACTPurposeBiodegradable elastomers, which can possess favorable mechanical properties and degradation rates for soft tissue engineering applications, are more recently being explored as depots… Expand
Utility of 3'-[(18)F]fluoro-3'-deoxythymidine as a PET tracer to monitor response to gene therapy in a xenograft model of head and neck carcinoma.
Noninvasive imaging methodologies are needed to assess treatment responses to novel molecular targeting approaches for the treatment of squamous cell carcinoma of the head and neck (SCCHN). Computer… Expand
Anti-Amyloid Effects of Small Molecule Aβ-Binding Agents in PS1/APP Mice.
- A. Cohen, M. Ikonomovic, +9 authors W. Klunk
- Medicine, Chemistry
- Letters in drug design & discovery
- 1 September 2009
AIMS: One promising approach for treatment of Alzheimer's disease (AD) is use of anti-amyloid therapies, based on the hypothesis that increases in amyloid-beta (Aβ) deposits in brain are a major… Expand
Cardiac Targeting Peptide, a Novel Cardiac Vector: Studies in Bio-Distribution, Imaging Application, and Mechanism of Transduction
Our previous work identified a 12-amino acid peptide that targets the heart, termed cardiac targeting peptide (CTP). We now quantitatively assess the bio-distribution of CTP, show a clinical… Expand
Modeling analysis of the CB1 PET tracer [11C]OMAR in rhesus monkeys and humans
- M. D. Normandin, D. Weinzimmer, +7 authors Y. Huang
- Computer Science, Psychology
- 1 August 2010
Methods: Three rhesus monkeys underwent a total of 20 scans on the Focus220. PET data were acquired for 120 min after a bolus injection of 4.2±0.6 mCi [C]OMAR. In 6 self-blocking scans, unlabeled… Expand
The high-affinity peripheral benzodiazepine receptor ligand [C-11]DAA1106 results in improved delineation of neuroinflammatory lesions in a rodent model of disease compared to [C-11]PK11195