Neal M. Patel

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The hybrid cellular automaton (HCA) algorithm is a methodology developed to simulate the process of structural adaptation in bones. This methodology incorporates a distributed control loop within a structure in which ideally localized sensor cells activate local processes of the formation and resorption of material. With a proper control strategy, this(More)
In this investigation a robotic system's dynamic performance is optimized for high reliability under uncertainty. The dynamic capability equations (DCE) allow designers to predict the dynamic performance of a robotic system for a particular configuration and reference point on the end-effector (i.e.,point design). Here the DCE are used in conjunction with a(More)
BACKGROUND Patients with hepatitis C virus (HCV) with or without human immunodeficiency virus (HIV) achieve high sustained virological response (SVR) rates on sofosbuvir (SOF)-containing regimens in clinical trials. Real world data on patients coinfected with HCV and HIV treated with SOF-based regimens are lacking. METHODS This observational cohort study(More)
Hepatitis C virus (HCV) recurrence after liver transplantation (LT) is associated with worse outcomes. The combination of ledipasvir (LDV) and sofosbuvir (SOF) has been approved for HCV treatment after LT, but there are limited data on the effectiveness and safety of LDV/SOF in the "real-world" setting. This multicenter study is the largest report to date(More)
In this research, a stochastic simulation based design tool that facilitates design in a dynamic environment is developed. The simulation includes a full dynamic model of an Autonomous Underwater Vehicle (AUV) that was developed to evaluate the effectiveness of such a craft given a set of physical attributes. These attributes include but are not limited to:(More)
Cellular automata (CAs) have been used as an alternative to represent macroscopic behavior of continuum systems governed by non-linear partial differential equations (PDEs). This task is generally accomplished using simple rules that represent the micromechanics of the system. CA models are composed of regular lattice of cells or automata. Each automaton(More)
The evaluation of patients with diffuse parenchymal lung diseases (DPLD), particularly the idiopathic interstitial pneumonias (IIP), often requires a multidisciplinary team approach. A surgical lung biopsy may be necessary for a confident diagnosis, particularly in patients with atypical clinical/radiological presentations.1 However, surgical lung biopsies(More)
AIM To determine risk factors associated with hepatitis C virus (HCV) treatment failure after direct acting antivirals in patients with complex treatment histories. METHODS All HCV mono-infected patients who received treatment at our institution were queried. Analysis was restricted to patients who previously failed treatment with boceprevir (BOC) or(More)
1. Abstract Cellular automaton (CA) models have been used to simulate biological phenomena over sixty years. Recently their principles have been applied to structural topology optimization using hybrid cellular automaton (HCA) models, which combines CA local design rules with finite element analysis. Different control strategies have been incorporated into(More)
A number of neurological disorders arise from perturbations in biochemical signaling and protein complex formation within neurons. Normally, proteins form networks that when activated produce persistent changes in a synapse's molecular composition. In hippocampal neurons, calcium ion (Ca2+) flux through N-methyl-D-aspartate (NMDA) receptors activates(More)