Neal H Shorstein

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PURPOSE To evaluate post-cataract-surgery endophthalmitis rates in relation to changing practice patterns in antibiotic administration. SETTING Kaiser Permanente, Diablo Service Area, California. DESIGN Ecological time-trend study. METHODS During 2007 through 2011, 3 time periods were identified based on increasing adoption of intracameral injections(More)
IMPORTANCE Intracameral injection of cefuroxime sodium (1 mg/0.1 mL) has been reported to reduce the risk of endophthalmitis following cataract surgery. In the United States it must be compounded, which is subject to dilution error. We describe a series of 13 eyes that received intracameral injection of cefuroxime sodium, 9 mg/0.1 mL, intraoperatively. (More)
BACKGROUND Antibiotic prophylaxis in cataract surgery is intended to minimize endophthalmitis. We describe pathogenic organisms, antibiotic sensitivities and antibiotic prophylaxis in culture-proven endophthalmitis cases. DESIGN Retrospective consecutive case series and community-based setting were used. PARTICIPANTS Two hundred fifteen cases of(More)
Recent studies have shown that chronic, but not acute, treatment with several different antidepressant drugs decreases the density of serotonin2 (5HT2) receptors in the cerebral cortex (Peroutka and Snyder, 1980a). It was found that combined administration of antidepressant drugs with alpha 2 antagonists could accelerate this down-regulation of 5HT2(More)
AIMS Reliance on intraocular pressure, optic nerve cupping changes, nerve fibre layer integrity, and visual field changes may delay treatment of glaucoma since irreversible changes may have already occurred at the time of diagnosis. Abnormal pattern electrical retinal responses (PERR or PERG) have been demonstrated in patients with ocular hypertension (no(More)
PURPOSE To study the relationship of chemoprophylaxis and other factors with the occurrence of acute, clinical, postoperative macular edema. DESIGN Retrospective cohort study. The drug regimens consisted of postoperative topical prednisolone acetate (PA) alone or with a nonsteroidal anti-inflammatory drug (NSAID) or intraoperative subconjunctival(More)
PURPOSE Intracameral injection is an effective method for preventing infection, but no controlled study has been published in the United States. DESIGN We conducted an observational, longitudinal cohort study to examine the effect of topical and injected antibiotics on risk of endophthalmitis. PARTICIPANTS We identified 315 246 eligible cataract(More)
Nonsteroidal antiinflammatory drugs (NSAIDs) have become an important adjunctive tool for surgeons performing routine and complicated cataract surgery. These medications have been found to reduce pain, prevent intraoperative miosis, modulate postoperative inflammation, and reduce the incidence of cystoid macular edema (CME). Whether used alone,(More)