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Alzheimer disease (AD) is a medically and financially overwhelming condition, and incidence rates are expected to triple by 2050.Despite decades of research in animal models of AD, the disease remains incompletely understood, with few treatment options. This review summarizes historical and current AD research efforts, with emphasis on the disparity between(More)
Risk of developing Alzheimer's disease is increased by older age, genetic factors, and several medical risk factors. Studies have also suggested that dietary and lifestyle factors may influence risk, raising the possibility that preventive strategies may be effective. This body of research is incomplete. However, because the most scientifically supported(More)
Cognitive disorders of later life are potentially devastating. To estimate the relationship between saturated and trans fat intake and risk of cognitive disorders. PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched for studies reporting saturated or trans fat intake and incident dementia, Alzheimer's disease (AD), or mild(More)
BACKGROUND/OBJECTIVES To determine the effects of a low-fat plant-based diet program on anthropometric and biochemical measures in a multicenter corporate setting. SUBJECTS/METHODS Employees from 10 sites of a major US company with body mass index ≥ 25 kg/m(2) and/or previous diagnosis of type 2 diabetes were randomized to either follow a low-fat vegan(More)
In this issue of Developmental Cell, Hosios et al. (2016) take a rigorous and quantitative approach to analyze metabolite acquisition and allocation in proliferating cultured mammalian cells. This work clarifies what we know while providing a new analytical framework to undergird future work on the metabolism of proliferating cells.
Disease risk factors identified in epidemiological studies serve as important public health tools, helping clinicians identify individuals who may benefit from more aggressive screening or risk-modification procedures, allowing policymakers to prioritize intervention programs, and encouraging at-risk individuals to modify behavior and improve their health.(More)
BACKGROUND Limited evidence suggests that dietary interventions may offer a promising approach for migraine. The purpose of this study was to determine the effects of a low-fat plant-based diet intervention on migraine severity and frequency. METHODS Forty-two adult migraine sufferers were recruited from the general community in Washington, DC, and(More)
BACKGROUND Diabetic neuropathy is a common and often debilitating condition for which available treatments are limited. Because a low-fat plant-based diet has been shown to improve glycemic control in individuals with type 2 diabetes, we hypothesized that such a diet would reduce painful symptoms of diabetic neuropathy. METHODS In this 20-week pilot(More)
Using an approach developed in the context of human bioethics, we argue that chimpanzees in research can be regarded as vulnerable subjects. This vulnerability is primarily due to communication barriers and situational factors-confinement and dependency-that make chimpanzees particularly susceptible to risks of harm and exploitation in experimental(More)
We have found two inadvertent errors in our paper published in Nutrients [1]. On page 909, reference number 38, the first author should read " Ley " and not " Lev ". Additionally, the year cited should read " 2014 " and not " 2010 ". The final reference should read: Associations between red meat intake and biomarkers of inflammation and glucose metabolism(More)