Neal D. Atkins

Learn More
As an inflammatory airway disease, asthma is expected to be associated with an increase in airway blood flow. We therefore compared airway mucosal blood flow (Qaw) among normal subjects (n = 11) and patients with stable asthma receiving (n = 13) or not receiving (n = 10) long-term inhaled glucocorticosteroid (GS) therapy. Qaw was calculated from the uptake(More)
The respiratory inductive plethysmograph, a monitor of ventilation that does not require a connection from the airway, was validated against spirometry during moderate exercise using a bicycle ergometer and a treadmill. One hundred seventy-three of 200 breaths during bicycle exercise from 6 young adults and 211 of 242 breaths during treadmill walking were(More)
The purpose of this investigation was to assess the density-dependent flow-volume components of the forced vital capacity using simultaneous spirometry, respiratory inductive plethysmography, and body plethysmography in the detection of small airway disease. The forced vital capacity was measured during air, helium-oxygen and sulfur-hexafluoride breathing(More)
We used a new non-invasive monitor of ventilation, the respiratory inductive plethysmograph, to determine the effects of breathing through a mouthpiece (with nose clip) and breathing through external dead spaces on ventilation at rest and during exercise. Six normal young subjects were studied during 5-min sequential periods at rest, submaximal exercise on(More)
The purpose of this investigation was to assess the effectiveness of the time-volume and flow-volume components of the forced vital capacity measured by simultaneous spirometry, respiratory inductive plethysmography, and body plethysmography in detecting small airway disease. Spirometry measured the exit of gas from the lungs, whereas body plethysmography(More)
Wanner, Adam, Eliana S. Mendes, and Neal D. Atkins. A simplified noninvasive method to measure airway blood flow in humans. J Appl Physiol 100: 1674–1678, 2006; doi:10.1152/japplphysiol.01349.2005.— Our laboratory has previously developed and validated a noninvasive soluble gas uptake method to measure airway blood flow (Q̇aw) in humans (Onorato DJ,(More)
We examined the effect of animal strain, type of spasmogen, and mode of spasmogen administration on the pattern of lung mechanical responses in intubated and mechanically ventilated mice. We determined the response in inspiratory respiratory system resistance (Rrs) and inspiratory static respiratory system compliance (Crs) to increasing doses of inhaled or(More)
We measured the uptake of the soluble inert gas dimethyl ether (DME) from a segment of the conducting airways to estimate mucosal blood flow (Qaw) noninvasively. The subjects inhaled, from the functional residual capacity position, a 300-ml gas mixture containing 35% DME, 8% helium, 35% oxygen, and the balance nitrogen; they held their breath for 5 s and(More)