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Fibrin deposition is a common accompaniment of renal allograft rejection, indicating disruption of the normal physiologic balance between procoagulant and anticoagulant pathways. In vitro, tumor… (More)
The mechanism by which leukotriene D4 (LTD4) induces airway narrowing in man is unclear. We have investigated this by examining the effect of the calcium channel blocker verapamil on the sensitivity… (More)
Themechanism bywhichleukotriene D4(LTD4)induces airway narrowing inman is unclear. Wehaveinvestigated this byexamining theeffect ofthecalcium channel blocker verapamil on thesensitivity ofinvitro… (More)
Airwayresponsiveness tomethacholine varies betweennormalpeople andis increased inpatients withasthma. Theimportance ofairway smoothmuscle sensitivity indeter- mining invivoresponsiveness isunknown.… (More)
Airway responsiveness tohistamine inmanmaybedetermined bythesmooth muscle sensitivity tohistamine ortotheinteraction between vagal nerveinput andsmoothmuscle sensitivity. We havecompared… (More)