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In Parkinson's disease (PD), iron elevation in specific brain regions as well as selective loss of dopaminergic neurons is a major pathologic feature. A reliable quantitative measure of iron deposition is a potential biomarker for PD and may contribute to the investigation of iron-mediated PD. The primary purpose of this study is to assess iron variations(More)
Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder with variable clinicopathologic phenotypes and underlying neuropathologic mechanisms. Each clinical phenotype has a unique set of motor symptoms. Tremor is the most frequent initial motor symptom of PD and is the most difficult symptom to treat. The dentate nucleus (DN) is a deep(More)
Functional connectivity (FC) analysis with data collected as continuous tasks and activation analysis using data from block-design paradigms are two main methods to investigate the task-induced brain activation. If the concatenated data of task blocks extracted from the block-design paradigm could provide equivalent FC information to that derived from(More)
The dentate nucleus (DN) of the cerebellum is the major output nucleus of the cerebellum and is rich in iron. Quantitative susceptibility mapping (QSM) provides better iron-sensitive MRI contrast to delineate the boundary of the DN than either T2-weighted images or susceptibility-weighted images. Prior DN atlases used T2-weighted or susceptibility-weighted(More)
Dynamic functional connectivity analysis, a rapidly growing method, has been demonstrated to provide new spatiotemporal information about how brain motor network would reorganize from rest to motor tasks. Phase synchronization analysis, which has been widely applied in EEG-based FC analysis, is a promising alternative method in dynamic FC analysis. In this(More)
Magnetic resonance spectroscopy (MRS) is the only biomedical imaging method that can noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid (GABA) in the human brain. Its increasing popularity has been aided by improvements in scanner hardware and acquisition methodology, as well as by broader access to pulse sequences that(More)
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