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Programmed cell death, or apoptosis, is important in homeostasis of the immune system: for example, non-functional or autoreactive lymphocytes are eliminated through apoptosis. One member of the tumour necrosis factor receptor (TNFR) family, Fas (also known as CD95 or Apo-1), can trigger cell death and is essential for lymphocyte homeostasis. FADD/Mort1 is(More)
For a number of reasons, even the best query optimizers can very often produce sub-optimal query execution plans, leading to a significant degradation of performance. This is especially true in databases used for complex decision support queries and/or object-relational databases. In this paper, we describe an algorithm that detects sub-optimality of a(More)
This paper presents a number of new techniques for parallelizing geo-spatial database systems and discusses their implementation in the Paradise object-relational database system. The effectiveness of these techniques is demonstrated using a variety of complex geo-spatial queries over a 120 GB global geo-spatial data set.
FADD/Mort1, initially identified as a Fas-associated death-domain containing protein, functions as an adapter molecule in apoptosis initiated by Fas, tumor necrosis factor receptor-I, DR3, and TRAIL-receptors. However, FADD likely participates in additional signaling cascades. FADD-null mutations in mice are embryonic-lethal, and analysis of FADD(-)/- T(More)
In this paper we describe the design and implementation of OPT++, a tool for Extensible Database Query Optimization that uses an object-oriented design to simplify the task of implementing, extending, and modifying an optimizer. Building an optimizer using OPT++ makes it easy to extend the query algebra (to add new query algebra operators and physical(More)
The lymphocyte cell-surface Ag CD38 catabolizes NAD to adenosine 5' diphosphoribose (ADPR) and cyclic ADPR (cADPR). We show here that the soluble extracellular domain of CD38 (sCD38) mediates ADP ribosylation of several proteins. This was demonstrated by mass spectrometric analyses which revealed the addition of mass in units of 541.1 Da to these proteins,(More)
FADD is an adapter protein that was originally isolated as a transducer of apoptotic signals for death domain-containing receptors. However, FADD-deficient mice are embryonic lethal and FADD(-/-) T cells developed from FADD(-/-) embryonic stem cells in the RAG-1(-/-) hosts lack the full potential to proliferate when stimulated through their T-cell receptor(More)
Progression through the cell cycle is a tightly controlled process that integrates signals generated at the plasma membrane with the proteins that form the cell cycle machinery. The current study chronicles the induction of cyclins, cyclin-dependent kinases (cdk), and cdk inhibitors in low density primary mouse B lymphocytes after anti-immunoglobulin plus(More)