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We have performed a comprehensive evaluation of single-nucleotide polymorphisms (SNPs) and haplotypes in the human TAS1R gene family, which encodes receptors for sweet and umami tastes. Complete DNA sequences of TAS1R1-, TAS1R2-, and TAS1R3-coding regions, obtained from 88 individuals of African, Asian, European, and Native American origin, revealed(More)
The ubiquitous enzyme, dihydrofolate reductase (DHFR), is a well-studied metabolic enzyme of significant pharmacological relevance. The past research studies have shown that DHFR has emerged as an important therapeutic target for the treatment of various diseases including cancers, bacterial and protozoal infections, and the opportunistic infections that(More)
Butyrylcholinesterase present in the serum, heart, lung, intestine, liver, and kidney plays an important role in the metabolism of ester containing compounds. Several neuronal groups solely show the activity of BChE in the human brain, such as in the inhibition or the absence of AChE, BChE can replace AChE in the degradation of acetylcholine ACh. Such(More)
Microtubules have always remained a mainstay in the discussion of anti-cancer drugs. Research is being carried out since over a decade on the microtubule-binding agents. The already present drugs have acquired clinical disadvantages or limitations, most importantly, the acquired resistance. Microtubule-stabilizing anti-mitotic agents (MSAAs) has proved(More)
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