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C5a controls TLR-induced IL-10 and IL-12 production independent of phosphoinositide 3-kinase.
- Natsumi Okazaki, K. Hazeki, T. Izumi, K. Nigorikawa, O. Hazeki
- BiologyJournal of biochemistry
- 1 March 2011
The result indicates that the C5a action isPI3K-independent; neither class IA nor class IB PI3K subtype is involved in this regulation, and the actions of C 5a were sensitive to pertussis toxin and PD98059, suggesting a role of G protein-mediated activation of the Erk1/2 pathway.
Specific role of phosphoinositide 3-kinase p110alpha in the regulation of phagocytosis and pinocytosis in macrophages.
It is indicated that phagocytosis and fluid-phase pinocytotic of larger molecules are dependent on the lipid kinase activity of p110alpha, whereas pinocyTosis via clathrin-coated and small non-coating vesicles may depend on subtypes of PI3Ks other than class I.
Establishment of DNA methylation patterns of the Fibrillin1 (FBN1) gene in porcine embryos and tissues
- Yoshikazu Arai, K. Umeyama, J. Ohgane
- BiologyThe Journal of reproduction and development
- 22 January 2017
The results suggest that the establishment of the DNA methylation pattern within the FBN1 CpG island shore occurs after the blastocyst stage, likely during organogenesis.
DNA methylation ambiguity in the Fibrillin-1 (FBN1) CpG island shore possibly involved in Marfan syndrome
- Yoshikazu Arai, K. Umeyama, J. Ohgane
- Biology, MedicineScientific Reports
- 24 March 2020
The ratio of the transcriptionally active hypomethylated WT allele was altered during cellular passage and highly correlated with FBN1 mRNA level compared with that in the KO allele, suggesting that the functional FBN 1 mRNA levels were affected by DNA methylation of the WT allele.