Natscha Erlach

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Upregulation of cyclooxygenase-2 (COX-2) and prostaglandin-dependent vascularisation in small adenomatous polyps is an essential part of colon carcinogenesis. To study the underlying cellular mechanisms, LT97 and Caco2 human colorectal tumour cells not expressing endogenous COX-2 were exposed to 1 microM prostaglandin E(2) (PGE(2)) in their medium. At 30(More)
We investigated the expression of all members of the EGFR family and several of their ligands (EGF, TGFa, HB-EGF, amphiregulin, betacellulin, epiregulin, neuregulin 1-4) in human hepatoma cell lines (Hep3B and HepG2) and liver tumors. HepG2 and Hep3B cells expressed three of the four receptors and the majority of the investigated ligands, indicating(More)
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