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The highly selective metabotropic glutamate (mGlu)2/3 receptor agonist LY379268 [(-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate] completely suppresses rapid eye movement (REM) sleep and strongly depresses theta (6-10 Hz) and high-frequency (10-60 Hz) power in the waking and nonrapid eye movement (NREM) EEG, effects consistent with depressed brain(More)
STUDY OBJECTIVES Slow wave EEG activity in NREM sleep decreases by more than 60% between ages 10 and 20 years. Slow wave EEG activity also declines across NREM periods (NREMPs) within a night, and this decline is thought to represent the dynamics of sleep homeostasis. We used longitudinal data to determine whether these homeostatic dynamics change across(More)
OBJECTIVES Sleep problems represent a worldwide health concern but their prevalence and impacts are unknown in most non-European/North American countries. This study aimed to evaluate sleep-wake patterns, sleep quality and potential correlates of poor sleep in a sample of the urban Georgian population. METHODS Analyses are based on 395 volunteers (267(More)
STUDY OBJECTIVES (1) To determine whether children and elderly exhibit the atypical kinetics of very low frequency (VLF) power found in young adults, (2) to test the hypothesis that variations in "delta" bandwidth designations can explain discrepancies in whether normalized delta power density declines across non-rapid eye movement periods (NREMPs) linearly(More)
STUDY OBJECTIVES The steep decline in slow-wave (delta) electroencephalogram (EEG) intensity across adolescence is a prominent feature of late brain maturation. As a first step in determining whether the adolescent delta decline is similar in both sexes, we compared cross-sectional sleep EEG data from 9- and 12-year-old boys and girls. DESIGN All-night(More)
Although traumatic events are presumed to cause sleep disturbances, particularly insomnia, sleep in populations subjected to forced displacement has received little attention. The present study examined the prevalence of insomnia and associated factors in internally displaced persons (IDPs) from Abkhazia 15 years after displacement to Tbilisi. Detailed(More)
Recent evidences suggest that posttraumatic stress disorder (PTSD) is associated with sleep disturbances following the traumatic events. However, the exact nature of the relationship between disturbed sleep and PTSD is unclear. The present study examined the development of PTSD and insomnia in the population subjected to force displacement from Shida(More)
Saccade-like eye movements are the most prominent phasic component of rapid eye movement (REM) sleep. Eye movement density (EMD) appears to be negatively related to sleep depth. Thus, EMD is depressed by sleep deprivation. We sought to determine in 19 young normal (YN) and 19 elderly normal (EN) subjects: (a) whether EMD is correlated with delta EEG in(More)
Hypnogenic structures are mainly located in the preoptic area of the hypothalamus. The number of Fos-immunoreactive neurons in the ventrolateral preoptic area (vlPOA) and in the median preoptic nucleus (MnPN) is positively correlated with the amount of preceding sleep. Majority of neurons recorded in these nuclei exhibit elevated discharge rates during(More)
Sleep-wake patterns and the electroencephalogram (EEG) during sleep undergo fundamental changes during adolescence. Scientific evidence indicates that these changes represent components of an extensive maturational brain remodeling process. Sleep during periods of brain maturation appears to be particularly important for health and behavior. Adolescents'(More)