Nathaniel Zhu

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This study describes a new methodology for delivering cultured autologous keratinocytes to wounds on a sterile medical grade polymer coated with a chemically defined plasma polymerised functional surface containing 20% carboxylic acid (referred to as PPS). Seven patients (two acute major burns and five chronic non-healing wounds) were treated with(More)
Group 2 innate lymphoid cells (ILC-2s) regulate immune responses to pathogens and maintain tissue homeostasis in response to cytokines. Positive regulation of ILC-2s through ICOS has been recently elucidated. We demonstrate here that PD-1 is an important negative regulator of KLRG1+ ILC-2 function in both mice and humans. Increase in KLRG1+ ILC-2 cell(More)
CD4+ T-helper subsets drive autoimmune chronic graft-versus-host disease, a major complication after allogeneic bone marrow transplantation. However, it remains unclear how specific T-helper subsets contribute to chronic graft-versus-host disease. T-helper type 1 cells are one of the major disease-mediating T-cell subsets and require interferon-γ signaling(More)
differential responsiveness of these cell lines to IL-8. IP-Western analysis revealed that CXCR1 expression is higher than that of CXCR2 in both cell lines. Flow cytometry and immunocytochemistry demonstrated detectable CXCR1 and CXCR2 cell surface receptor expression in PC3 cells, but also revealed that CXCR1 and CXCR2 are predominantly localised to(More)
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