Learn More
BACKGROUND Activation Induced cytidine Deaminase (AID) targets the immunoglobulin genes of activated B cells, where it converts cytidine to uracil to induce mutagenesis and recombination. While essential for immunoglobulin gene diversification, AID misregulation can result in genomic instability and oncogenic transformation. This is classically illustrated(More)
BACKGROUND Somatic hypermutation introduces base substitutions into the rearranged and expressed immunoglobulin (Ig) variable regions to promote immunity. This pathway requires and is initiated by the Activation Induced Deaminase (AID) protein, which deaminates cytidine to produce uracils and UG mismatches at the Ig genes. Subsequent processing of uracil by(More)
Welcome to the 2 nd edition of The Biology Times, The School of Biological Sciences has worked all summer long preparing for upcoming year while graduate students along with faculty members have effortlessly worked on the various research projects being conducted at Illinois State University. The end of summer is quickly approaching but there has been no(More)
  • 1