Nathaniel R. Twarog

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We describe how inflation, the act of mapping a 2D silhouette to a 3D region, can be applied in two disparate problems to offer insight and improvement: silhouette part segmentation and image-based material transfer. To demonstrate this, we introduce Puffball, a novel inflation technique, which achieves similar results to existing inflation approaches --(More)
Ewing sarcoma (EWS) is a tumor of the bone and soft tissue that primarily affects adolescents and young adults. With current therapies, 70% of patients with localized disease survive, but patients with metastatic or recurrent disease have a poor outcome. We found that EWS cell lines are defective in DNA break repair and are sensitive to PARP inhibitors(More)
Understanding and exploiting the abilities of the human visual system is an important part of the design of usable user interfaces and information visualizations. Good design enables quick, easy and veridical perception of key components of that design. An important facet of human vision is its ability to seemingly effortlessly perform "perceptual(More)
With combination therapies becoming increasingly vital to understanding and combatting disease, a reliable method for analyzing combined dose response is essential. The importance of combination studies both in basic and translational research necessitates a method that can be applied to a wide range of experimental and analytical conditions. However,(More)
Phenotypic screening through high-content automated microscopy is a powerful tool for evaluating the mechanism of action of candidate therapeutics. Despite more than a decade of development, however, high content assays have yielded mixed results, identifying robust phenotypes in only a small subset of compound classes. This has led to a combinatorial(More)
Paediatric solid tumours arise from endodermal, ectodermal, or mesodermal lineages. Although the overall survival of children with solid tumours is 75%, that of children with recurrent disease is below 30%. To capture the complexity and diversity of paediatric solid tumours and establish new models of recurrent disease, here we develop a protocol to produce(More)
We describe how inflation, the act of mapping a 2D silhouette to a 3D region, can be applied in two disparate problems to offer insight and improvement: silhouette part segmentation and imagebased material transfer. To demonstrate this, we introduce Puffball, a novel inflation technique, which achieves similar results to existing inflation approaches –(More)
A diverse library of pre-fractionated plant extracts, generated by an automated high-throughput system, was tested using an in vitro anti-malarial screening platform to identify known or new natural products for lead development. The platform identifies hits on the basis of in vitro growth inhibition of Plasmodium falciparum and counter-screens for(More)
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