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TeraGrid is a national-scale computational science facility supported through a partnership among thirteen institutions, with funding from the US National Science Foundation [1]. Initially created through a Major Research Equipment Facilities Construction (MREFC [2]) award in 2001, the TeraGrid facility began providing production computing, storage,(More)
Single nucleotide polymorphisms (SNPs) are abundant in genomes of all species and biologically informative markers extensively used across broad scientific disciplines. Newly identified SNP markers are publicly available at an ever-increasing rate due to advancements in sequencing technologies. Efficient, cost-effective SNP genotyping methods to screen(More)
–Portals Direct I/O ("PDIO") is a special-purpose middleware infrastructure for writing data from compute processor memory on Portals-enabled compute nodes to remote agents anywhere on the WAN in real-time. The prototype implementation provided a means for aggregation of outgoing data through multiple load-balanced routing daemons, end-to-end parallel data(More)
We have developed a novel analytic capability for scientists and engineers to obtain insight from ongoing large-scale parallel unstructured mesh simulations running on thousands of processors. The breakthrough is made possible by a new approach that visualizes partial differential equation (PDE) solution data simultaneously while a parallel PDE solver(More)
* Growing compute capacity coupled with advances in parallel filesystem performance and stability mean that HPC users will inevitably create and store larger datasets. If data residing on parallel filesystems is not efficiently offloaded to archival storage, disruptions in the compute cycle will occur. Hierarchical storage caches are a vital aspect of the(More)
PSC has architected and delivered the TCS-1 machine, a Terascale Computing System for use in unclassified research. PSC has enhanced the effective usability and utilization of this resource by providing custom I/O solutions in four key areas: high-performance communication, high-performance file migration, checkpoint/recovery and an updated hierarchical(More)
Yersinia pestis was introduced to North America around 1900 and leads to nearly 100% mortality in prairie dog (Cynomys spp.) colonies during epizootic events, which suggests this pathogen may exert a strong selective force. We characterized genetic diversity at an MHC class II locus (DRB1) in Gunnison's prairie dog (C. gunnisoni) and quantified population(More)
Nosocomial acquisition of Clostridium difficile is well documented, yet recent studies have highlighted the importance of community acquired infections and identified community associated reservoirs for this pathogen. Multiple studies have implicated companion pets and farm animals as possible sources of community acquired C. difficile infections in humans.(More)
On August 3rd, 2000, the National Science Foundation announced the award of $45 million to the Pittsburgh Supercomputing Center to provide "terascale" computing capability for U.S. researchers in all science and engineering disciplines. This Terascale Computing System (TCS) will be built using commodity components. The computational engines will be Compaq(More)