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Hemoglobin (Hb)-based O2 carriers (HBOC) are undergoing extensive development as potential "blood substitutes." A major problem associated with these molecules is an increase in microvascular permeability and peripheral vascular resistance. In this paper, we utilized bovine lung microvascular endothelial cell monolayers and simultaneously measured(More)
Total sodium space and total body sodium contents were determined in four groups of individuals with the aid of radiosodium24. There appears to be an increase in these values with age, but the presence of well compensated cardiovascular disease in the older age group does not significantly alter the magnitude of these measurements. When congestive failure(More)