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" A footnote in this paper indicates that it was presented at a Conference of Regional Statisticians in Bethesda in May 1965. That actually was not the case—I had presented another paper but submitted the instant one for publication, a case of false pretenses. " Sometime in 1964, I followed through on a suggestion in my 1963 extension 1 to the original 1959(More)
Part I of this report appeared in the previous issue (Br. J. Cancer (1976) 34,585), and discussed the design of randomized clinical trials. Part II now describes efficient methods of analysis of randomized clinical trials in which we wish to compare the duration of survival (or the time until some other untoward event first occurs) among different groups of(More)
The Medical Research Council has for some years encouraged collaborative clinical trials in leukaemia and other cancers, reporting the results in the medical literature. One unreported result which deserves such publication is the development of the expertise to design and analyse such trials. This report was prepared by a group of British and American(More)
A previous study of twins with Parkinson's disease (PD) revealed low concordance, suggesting that genetic factors play a minor role in the etiology of PD. To identify possible environmental determinants of PD while maximally controlling for hereditary factors, 31 monozygotic twin pairs discordant for PD were interviewed by telephone. Information about(More)
Average annual age-adjusted incidence rates of parkinsonism-dementia complex were obtained for the 19 election districts of Guam from 1956 through 1985. The highest rates were found in the southern and central districts, and the lowest rates were found in the northern and western districts. Geographic and temporal patterns of incidence were associated with(More)
Using a case registry, we investigated the temporal occurrence of motor neuron disease (MND) on Guam. MND with onset during 1941-85 was documented in 434 Chamorros and 9 non-Chamorro migrants who had lived on Guam before onset. Increased median age at onset and decreased age-adjusted incidence rates (since the early 1960s) were observed for Chamorros of(More)
practical familiarity with the problems of retrospective studies. My experience had been largely in the application of statistics and statistical thinking to laboratory investigations and Haenszel suggested that I augment his own work by any statistical concepts I thought appropriate. Those concepts were, in a way, simple and I was not satisfied to give(More)
A test for homogeneity of the effect of a factor in inducing disease in the various strata of a population should relate to the scaling in which homogeneity is anticipated. Popularity, it is the multiplicative effect on the odds ratio in which homogeneity is anticipated. An asymptotic test by M. Zelen (Biometrika 58:129-137, 1971) for homogeneity in this(More)
We investigated the geographic and familial occurrence of motor neuron disease (MND) on Guam, and then considered etiologic hypotheses related to cycad use and metal intoxication. The research was based on 303 Chamorros from Guam and 3 Chamorros from other Mariana Islands, all with MND onset on Guam during 1956-85. Inarajan and Umatac, two southern(More)
The principles of the Ederer-Myers-Mantel procedure for seeking evidence of disease clustering are reviewed. The procedure is based on cumulative empirical clusters, i.e., the largest frequency in a single time period or in two successive time periods, and comparing that cumulation with the expected cumulation of largest frequencies under random occurrence.(More)