Nathan H. Frank

  • Citations Per Year
Learn More
Disulfiram (DSF) delayed the appearance of diethylnitrosamine (DEN)-induced strand breaks in liver DNA of rats. The fragmentation of liver DNA produced by DEN was studied 4 and 24 h after administration of the carcinogen on alkaline sucrose gradients. A single dose of 500 mg/kg DSF given 1 h prior to carcinogen treatment delayed for at least 4 h the DEN(More)
We have studied the effects of disulfiram (DSF) administration on the metabolism of nitrosodiethylamine (NDEA) in rats during acute and chronic administration. DSF was found to have the following effects during the course of carcinogenesis: (a) marked decrease in the exhalation of 14CO2 derived from 14C-NDEA; (b) reduction of the total levels of DNA and RNA(More)
Die Alkylierungsrate von Guanin der Rattenleber DNA in 7 N-und O-6-Stellung wurde untersucht nach chronischer Gabe von unmarkiertem Nitrosodiäthylamin und einer abschließenden Dosis 14C markierter Substanz. Disulfiram vermindert die Alkylierungsrate in der DNA der Rattenleber. Es konnte ferner gezeigt werden, daß eine nicht fortlaufende Verabreichung von(More)
A new experimental approach was developed that can reduce the uncertainties in astrophysical rapid proton capture (rp) process calculations due to nuclear data. This approach utilizes neutron removal from a radioactive ion beam to populate the nuclear states of interest. Excited states were deduced by the gamma-decay spectra measured in a semiconductor(More)
C. C. Hall,1 E. M. Lunderberg,1 P. A. DeYoung,1,* T. Baumann,2 D. Bazin,2 G. Blanchon,3 A. Bonaccorso,4 B. A. Brown,2,5 J. Brown,6 G. Christian,2,5 D. H. Denby,1 J. Finck,7 N. Frank,2,5,† A. Gade,2,5 J. Hinnefeld,8 C. R. Hoffman,9,10 B. Luther,11 S. Mosby,2,5 W. A. Peters,2,5,‡ A. Spyrou,2,5 and M. Thoennessen2,5 1Department of Physics, Hope College,(More)
The neutron unbound ground state of (25)O (Z=8, N=17) was observed for the first time in a proton knockout reaction from a (26)F beam. A single resonance was found in the invariant mass spectrum corresponding to a neutron decay energy of 770_+20(-10) keV with a total width of 172(30) keV. The N=16 shell gap was established to be 4.86(13) MeV by the energy(More)
The effect of an in vivo treatment with the carboxylesterase inhibitor bis-p-nitrophenylphosphate (BNPP) on the hydrolysis of 1-(N-methyl-N-nitrosamino)-methylacetate (NNMA), 1-(N-methyl-N-nitrosamino)-methylbutyrate (NNMB), 1-(N-methyl-N-nitrosamino)-methylbenzoate (NNMBz) and 1-(N-methyl-N-nitrosamino)-methylpivaloate (NMMP) in rat tissue homogenates was(More)
Neutron decay spectroscopy of neutron-rich oxygen isotopes has been performed using the two-proton knock-out reaction 9Be(26Ne,X)24,23,22O. A combination of the knock-out of valence and core protons can explain the three observed spectra. These knock-out processes are selective and preferentially populate hole states. The observed narrow resonance state in(More)
W. A. Peters,1,2,* T. Baumann,2 B. A. Brown,1,2 J. Brown,3 P. A. DeYoung,4 J. E. Finck,5 N. Frank,1,2,† K. L. Jones,6,‡ J.-L. Lecouey,2,§ B. Luther,7 G. F. Peaslee,4 W. F. Rogers,8 M. Thoennessen,1,2 and J. A. Tostevin9 1Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48824, USA 2National Superconducting Cyclotron(More)