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Mechanisms of ATP-Dependent Chromatin Remodeling Motors.
Chromatin remodeling motors play essential roles in all DNA-based processes. These motors catalyze diverse outcomes ranging from sliding the smallest units of chromatin, known as nucleosomes, toExpand
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The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF2h
ISWI family chromatin remodeling motors use sophisticated autoinhibition mechanisms to control nucleosome sliding. Yet how the different autoinhibitory domains are regulated is not well understood.Expand
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Organization and Regulation of Chromatin by Liquid-Liquid Phase Separation
Genomic DNA is highly compacted in the nucleus of eukaryotic cells as a nucleoprotein assembly called chromatin1. The basic unit of chromatin is the nucleosome, where ∼146 base pair increments of theExpand
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Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome
The SNF2h remodeler slides nucleosomes most efficiently as a dimer, yet how the two protomers avoid a tug-of-war is unclear. Furthermore, SNF2h couples histone octamer deformation to nucleosomeExpand
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APC/C-dependent control of gene expression and cell identity
Metazoan development requires robust proliferation of progenitor cells, whose identities are established by tightly controlled transcriptional networks 1. As gene expression is globally inhibitedExpand
Single-Molecule Mechanistic Dissection of a Chromatin Remodeling Motor
Chromatin remodeling complexes are molecular motors that catalyze diverse structural rearrangements of the genetic material in eukaryotic cells. One such motor, human ACF, is involved in manyExpand
The nucleosomal acidic patch relieves auto-inhibition by the ISWI remodeler SNF 2 h 1 2
15 ISWI family chromatin remodeling motors use sophisticated autoinhibition mechanisms to 16 control nucleosome sliding. Yet how the different autoinhibitory domains are regulated is not 17 wellExpand
Histone dynamics within the nucleosome play a critical role in SNF2h-mediated nucleosome sliding
Elucidating the mechanisms by which ATP-dependent chromatin remodeling enzymes disrupt nucleosome structure is essential to understanding how chromatin states are established and maintained. A keyExpand