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Intravenous administration of the GABA agonist, muscimol, caused dose-dependent increases in the unit activity of substantia nigra pars compacta (dopamine) neurons and an inhibition of nigral pars reticulata cells. The depressant effects of the drug upon reticulata neurons were reversible by subsequent administration of the GABA antagonists, picrotoxin and(More)
Continuous intravenous infusion of levodopa was used for eight days to manage a parkinsonian patient with "on-off" fluctuations who underwent abdominoperineal resection for carcinoma of the rectum. Reasonable control of parkinsonism was obtained initially with small doses of levodopa, but more than 4 g daily were eventually required. No adverse effects on(More)
Because there is biochemical evidence of decreased GABAergic function in Parkinson's disease, sodium valproate, an inhibitor of GABA catabolism, was administered to eight Parkinsonian patients. Valproate treatment did not significantly alter any Parkinsonian feature, but tended to increase the dyskinesia in the "on-off" patients. The increased dyskinesias(More)
Absorption of levodopa was studied after administration by mouth and rectum. Given by mouth, levodopa benefited all 12 patients studied, and levodopa blood levels rose significantly (p less than 0.01). When it was given rectally, there was no rise in levodopa concentration in the blood and no clinical benefit. Rectally administered levodopa is therefore of(More)
Degeneration of dopamine (DA) containing neurons in the basal ganglia of Parkinsonian patients causes a reduction in cerebrospinal fluid (CSF) concentrations of the principal metabolite of dopamine, homovanillic acid (HVA). Not only are steady state HVA levels depressed, but there is substantial diminution in the rate of HVA accumulation in CSF during the(More)
Intravenous administration of increasing doses of the ergoline, lergotrile mesylate, caused a rapid, dose-dependent and haloperidol-reversible inhibition of unit activity of dopamine cells in the pars compacta of the rat substantia nigra. 6 microgram/kg caused significant depression of dopamine cell firing rates; 50% inhibition was achieved with a(More)
  • Abboud, H Floden, +114 authors Ra Breathprints
  • 2016
Impact of mild cognitive impairment on outcome following deep brain stimulation surgery for Parkinson's disease. Single-injection thoracic paravertebral block and postoperative analgesia after mastectomy: a retrospective cohort study. Reply: Conventional risk factors and cardiovascular outcomes of patients with inflammatory bowel disease with confirmed(More)