Nathan D. Schwalm

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Bacteroides thetaiotaomicron is a human gut symbiotic bacterium that utilizes a myriad of host dietary and mucosal polysaccharides. The proteins responsible for the uptake and breakdown of many of these polysaccharides are transcriptionally regulated by hybrid two-component systems (HTCSs). These systems consist of a single polypeptide harboring the domains(More)
The utilization of simple sugars is widespread across all domains of life. In contrast, the breakdown of complex carbohydrates is restricted to a subset of organisms. A regulatory paradigm for integration of complex polysaccharide breakdown with simple sugar utilization was established in the mammalian gut symbiont Bacteroides thetaiotaomicron, whereby(More)
Bacteroides spp. are members of the human gut microbiota that confer myriad benefits on their hosts. Among them is the provision of energy from otherwise indigestible polysaccharides comprising part of the host diet, lining the intestinal mucosal layer, and decorating the surface of other microbes. Bacteroides spp. devote ∼20% of their genomes to the(More)
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