Nathan D. Bos

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The cognitive and organizational challenges associated with `Big Data' have not received much research attention. We have begun an interview study of analysts who work in the computer network (cyber) defense (CND) area and have experienced changes in data scale affecting their analytical work. Our goal is to understand any changes in analysts' mental models(More)
What do game designers know about sustaining learner engagement? This paper analyzed the popular simulation game SimCity with the goal of identifying design principles that would be useful for educators. The term 'organic feedback' is used to describe how SimCity gradually increases the complexity of its simulations and gives players a constant, pleasing(More)
OBJECTIVE Varicella-zoster virus (VZV) infection may trigger the inflammatory cascade that characterizes giant cell arteritis (GCA). METHODS Formalin-fixed, paraffin-embedded GCA-positive temporal artery (TA) biopsies (50 sections/TA) including adjacent skeletal muscle and normal TAs obtained postmortem from subjects >50 years of age were examined by(More)
Varicella zoster virus (VZV) latency is characterized by limited virus gene expression and the absence of virus DNA replication. Investigations of VZV latency and reactivation have been hindered by the lack of an in vitro model of virus latency. Since VZV is an exclusively human pathogen, we used naturally infected human trigeminal ganglia (TG) obtained at(More)
Analysis of the frequency and PCR-quantifiable abundance of herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV) DNA in multiple biological replicates of cells from dissociated randomly distributed human trigeminal ganglia (TG) of four subjects revealed an increase in both parameters and in both viruses during 5 days of culture, with no(More)
Fig. 1: The Ocelot interface, refined by the user-centered design process. Abstract— Most cyber security research is focused on detecting network intrusions or anomalies through the use of automated methods, exploratory visual analytics systems, or real-time monitoring using dynamic visual representations. However, there has been minimal investigation of(More)
We report on the sensemaking breakout group at the Human Centered Big Data Research (HCBDR-2014) workshop. The authors are a multi-disciplinary team of invited researchers and stakeholders who participated in this breakout session. This report includes an overview of our discussions on the many research challenges associated with sensemaking within a big(More)