Nathalie K. Guimard

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The primary component of amyloid plaque in the brains of Alzheimer's patients is the 42 residue amyloid-beta-peptide (Abeta42). Although the amino acid residue sequence of Abeta42 is known, the molecular determinants of Abeta amyloidogenesis have not been elucidated. To facilitate an unbiased search for the sequence determinants of Abeta aggregation, we(More)
Preparative Macromolecular Chemistry, Polymerchemie, Karlsruhe Institute of Te Karlsruhe, Germany. E-mail: christopher.ba 45740 Institut für Biologische Grenzächen, Ka Hermann-von-Helmholtz Platz 1, 76344 Egg Leibniz-Institut für Polymerforschung Dres Germany Technische Universität Dresden, 01062 Dre ARC Centre of Excellence for Free-Radical School of(More)
A pair of monomers capable of undergoing reversible polymerization—based on reversible Diels–Alder (DA) chemistry—as a function of the applied reaction temperature is presented. Specifically, the reaction of isophorone bis(sorbic carbamate), a difunctional diene, with 1,4-phenylenebis(methylene) bis((diethoxyphosphoryl)methanedithioformate), a difunctional(More)
Preparative Macromolecular Chemistry, Polymerchemie, Karlsruhe Institute of Tech Karlsruhe, Germany. E-mail: christopher. 608-45740 ARC Centre of Excellence for Free-radical School of Chemistry, Australian National U E-mail: mcoote@rsc.anu.edu.au; Fax: +61 2 Leibniz-Institut für Polymerforschung Dres Germany Technische Universität Dresden, 01062 Dre Evonik(More)
Synthetic polymer chemistry has undergone two major developments in the last two decades. About 20 years ago, reversible-deactivation radical polymerization processes started to give access to a wide range of polymeric architectures made from an almost infinite reservoir of functional building blocks. A few years later, the concept of click chemistry(More)
Making light work of RAFT conjugation: a non-activated RAFT agent at the end of RAFT polymers can readily be coupled with ortho-quinodimethanes (photoenols) in a photo-triggered Diels-Alder reaction under mild conditions without catalyst. The method is universal and opens the door for the conjugation of a large number of RAFT-prepared polymers with(More)
Polymers capable of dynamic bonding/debonding reactions are of great interest in modern day research. Potential applications can be found in the fields of self-healing materials or printable networks. Since temperature is often used as a stimulus for triggering reversible bonding reactions, an analysis operating at elevated temperatures is very useful for(More)
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