Nathalie A Vikulova

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Using one-dimensional models of myocardial tissue, implemented as chains of virtual ventricular muscle segments that are kinematically connected in series, we studied the role of the excitation sequence in spatio-temporal organization of cardiac function. Each model element was represented by a well-verified mathematical model of cardiac electro-mechanical(More)
It has been shown that isolated sub-epicardial (EPI) and sub-endocardial (ENDO) myocytes have distinct electrical and mechanical properties in normal heart ventricle and differently respond to interventions. We utilized our electromechanical models of EPI and ENDO myocytes to simulate their responses to the acute ischemia and to predict effects of cell(More)
Mathematical models have been developed to describe interactions of electrical, mechanical and chemical processes in cardiomyocytes. The models simulate wide range of experimental data on excitation-contraction coupling and, more importantly, on mechanoelectric feedback in heart muscle. The model results clearly show that mechano-dependence of intracellular(More)
Based on the experimental evidence, we developed a one-dimensional (1D) model of heterogeneous myocardial tissue consisting of in-series connected cardiomyocytes from distant transmural regions using mathematical models of subendocardial and subepicardial cells. The regional deformation patterns produced by our 1D model are consistent with the transmural(More)
Myocardial heterogeneity is an attribute of the normal heart. We have developed integrative models of cardiomyocytes from the subendocardial (ENDO) and subepicardial (EPI) ventricular regions that take into account experimental data on specific features of intracellular electromechanical coupling in the guinea pig heart. The models adequately simulate(More)
The effect of acute myocardial ischemia on the electrical and mechanical function of cardiomyocytes was studied in the framework of a mathematical model of a single cardiomyocyte. Acute ischemia consequences were simulated via a combination of two factors--a reduction of intracellular ATP concentration and an increase in extracellular potassium(More)
Cardiac arrhythmias and long QT syndrome may be associated with increased sodium currents. Possible effects of enhanced function of sodium channels on the transmural gradient in the electrical and mechanical properties of myocardium have not been sufficiently studied. We used our cellular mathematical models to investigate effects of an increased late(More)
We utilized our earlier developed 1D mathematical model of the heart muscle strand to study contribution of the bilateral interactions between excitation and contraction on the cellular and tissue levels to the local and global myocardium function. Numerical experiments on the model showed that an initially uniform strand, formed on the inherently identical(More)
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