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Signaling by the transcription factor nuclear factor kappa B (NF-kappaB) involves its release from inhibitor kappa B (IkappaB) in the cytosol, followed by translocation into the nucleus. NF-kappaB regulation of IkappaBalpha transcription represents a delayed negative feedback loop that drives oscillations in NF-kappaB translocation. Single-cell time-lapse(More)
In previous work, we studied the behaviour of a model of part of the NF-kappaB signalling pathway. The model displayed oscillations that varied both in number, amplitude and frequency when its parameters were varied. Sensitivity analysis showed that just nine of the 64 reaction parameters were mainly responsible for the control of the oscillations when(More)
Ensemble species distribution models combine the strengths of several species environmental matching models, while minimizing the weakness of any one model. Ensemble models may be particularly useful in risk analysis of recently arrived, harmful invasive species because species may not yet have spread to all suitable habitats, leaving species-environment(More)
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