Natasha Gupta

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The Shank3 gene encodes a scaffolding protein that anchors multiple elements of the postsynaptic density at the synapse. Previous attempts to delete the Shank3 gene have not resulted in a complete loss of the predominant naturally occurring Shank3 isoforms. We have now characterized a homozygous Shank3 mutation in mice that deletes exon 21, including the(More)
SHANK3 (also known as PROSAP2) is a postsynaptic scaffolding protein at excitatory synapses in which mutations and deletions have been implicated in patients with idiopathic autism, Phelan-McDermid (aka 22q13 microdeletion) syndrome, and other neuropsychiatric disorders. In this study, we have created a novel mouse model of human autism caused by the(More)
INTRODUCTION Current treatment paradigms for metastatic renal cell carcinoma (mRCC) invoke a combination of surgical and systemic therapies. We sought to quantify trends in mortality and performance of lymphadenectomy, as well as impact on survival for patients with mRCC. METHODS The Surveillance, Epidemiology, and End Results registry (SEER) (1988-2011)(More)
BACKGROUND Disparities in access to kidney transplantation (KT) remain inadequately understood and addressed. Detailed descriptions of patient attitudes may provide insight into mechanisms of disparity. The aims of this study were to explore perceptions of dialysis and KT among African American adults undergoing hemodialysis, with particular attention to(More)
Our goals were to (1) identify risk factors associated with conversion from laparoscopic to open appendectomies and (2) establish criteria that predict the possibility of conversion to an open technique. We did a retrospective chart review of all patients who underwent laparoscopic appendectomies during a 5-year period (2004-2008). Preoperative risk(More)
The molecular changes responsible for inducing neuronal apoptosis are unknown. Rat cortical neurons were treated with x-irradiation 7 d after isolation to test for the role of DNA damage in neuronal death. The response of neurons to x-irradiation was compared with that of astrocytes that had been isolated 3 weeks earlier from newborn rats. At the time of(More)
BACKGROUND Incompatible live donor kidney transplantation is associated with an increased rate of antibody-mediated rejection (AMR) and subsequent transplant glomerulopathy. For patients with severe, oliguric AMR, graft loss is inevitable without timely intervention. METHODS We reviewed our experience rescuing kidney allografts with this severe AMR(More)
Foreign body aspiration into the airways is a significant cause of morbidity and mortality in pediatric patients, especially in children below 3 years of age. In the absence of clear history, the correct diagnosis is often missed. The clinical features may mimic asthma or pneumonia, resulting in delayed diagnosis. Cough or wheezing of sudden onset, reduced(More)
OBJECTIVES To understand the natural history of frailty after an aggressive surgical intervention, kidney transplantation (KT). DESIGN Prospective cohort study (December 2008-March 2014). SETTING Baltimore, Maryland. PARTICIPANTS Kidney transplantation recipients (N = 349). MEASUREMENTS The Fried frailty score was measured at the time of KT and(More)
BACKGROUND Frailty, a validated measure of physiologic reserve, predicts adverse health outcomes among adults with end-stage renal disease. Frailty typically is not measured clinically; instead, a surrogate-perceived frailty-is used to inform clinical decision-making. Because correlations between perceived and measured frailty remain unknown, the aim of(More)