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The Shank3 gene encodes a scaffolding protein that anchors multiple elements of the postsynaptic density at the synapse. Previous attempts to delete the Shank3 gene have not resulted in a complete loss of the predominant naturally occurring Shank3 isoforms. We have now characterized a homozygous Shank3 mutation in mice that deletes exon 21, including the(More)
INTRODUCTION Current treatment paradigms for metastatic renal cell carcinoma (mRCC) invoke a combination of surgical and systemic therapies. We sought to quantify trends in mortality and performance of lymphadenectomy, as well as impact on survival for patients with mRCC. METHODS The Surveillance, Epidemiology, and End Results registry (SEER) (1988-2011)(More)
BACKGROUND Incompatible live donor kidney transplantation is associated with an increased rate of antibody-mediated rejection (AMR) and subsequent transplant glomerulopathy. For patients with severe, oliguric AMR, graft loss is inevitable without timely intervention. METHODS We reviewed our experience rescuing kidney allografts with this severe AMR(More)
The molecular changes responsible for inducing neuronal apoptosis are unknown. Rat cortical neurons were treated with x-irradiation 7 d after isolation to test for the role of DNA damage in neuronal death. The response of neurons to x-irradiation was compared with that of astrocytes that had been isolated 3 weeks earlier from newborn rats. At the time of(More)
BACKGROUND AND OBJECTIVES Disparities in kidney transplantation remain; one mechanism for disparities in access to transplantation (ATT) may be patient-perceived concerns about pursuing transplantation. This study sought to characterize prevalence of patient-perceived concerns, explore interrelationships between concerns, determine patient characteristics(More)
Our goals were to (1) identify risk factors associated with conversion from laparoscopic to open appendectomies and (2) establish criteria that predict the possibility of conversion to an open technique. We did a retrospective chart review of all patients who underwent laparoscopic appendectomies during a 5-year period (2004-2008). Preoperative risk(More)
BACKGROUND Type 2 diabetes mellitus is a multisystem disorder that is associated with number of complications. Patient's awareness and practices are crucial components in reducing the burden of diseases and its complications. AIM To assess patient's knowledge about their disease and its complications, practices, treatment seeking behavior and average(More)
SHANK3 (also known as PROSAP2) is a postsynaptic scaffolding protein at excitatory synapses in which mutations and deletions have been implicated in patients with idiopathic autism, Phelan-McDermid (aka 22q13 microdeletion) syndrome, and other neuropsychiatric disorders. In this study, we have created a novel mouse model of human autism caused by the(More)
Maximizing deceased donation rates can decrease the organ shortage. Non-transplant physicians play a critical role in facilitating conversion of potential deceased donors to actual donors, but studies suggest that physicians lack knowledge about the organ donation process. As residency and fellowship are often the last opportunities for formal medical(More)
OBJECTIVES To understand the natural history of frailty after an aggressive surgical intervention, kidney transplantation (KT). DESIGN Prospective cohort study (December 2008-March 2014). SETTING Baltimore, Maryland. PARTICIPANTS Kidney transplantation recipients (N = 349). MEASUREMENTS The Fried frailty score was measured at the time of KT and(More)