Natasha Bollegala

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Agitation, restlessness, and aggression are frequent neurobehavioural sequelae in the early stages of recovery from traumatic brain injury (TBI). These behavioural symptoms disrupt patient care and impede rehabilitation efforts. We review the current literature (1985 onwards) examining the pharmacological management of post-TBI agitation in both acute and(More)
The use of typical neuroleptics has always been the mainstay of treatment for delirium following traumatic brain injury (TBI). Given the recent application of atypical neuroleptics to various psychiatric conditions formerly treated with typical neuroleptics, one questions whether this new class of drugs is superior to its predecessor in treating delirium(More)
BACKGROUND & AIMS Patients with inflammatory bowel diseases (IBD) are hospitalized frequently. We sought to identify factors associated with risk for IBD-related readmission to the hospital. METHODS We performed a retrospective analysis of 26,403 patients hospitalized for IBD from 2004 through 2010 using the Canadian Institute for Health Information(More)
BACKGROUND The transition from pediatric to adult care for inflammatory bowel disease (IBD) is poorly understood. AIMS To characterize this transfer of care, health resource utilization was assessed. METHODS Patients transferred between 1999 and 2008 were studied. Utilization of health resources one year before transfer and one year after transfer was(More)
The incidence of inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), has increased in pediatric populations over the last decade. Patients diagnosed during childhood often survive well into adulthood, and therefore their healthcare requires transfer to an adult gastroenterologist, usually at age 18 years.(More)
BACKGROUND & AIMS Elderly patients may be at increased risk for poor outcomes after surgery for inflammatory bowel disease (IBD). We investigated postoperative mortality and the incidence of complications in elderly patients with IBD. METHODS We identified patients who underwent major IBD-related abdominal surgery using the American College of Surgeons(More)
BACKGROUND Patients diagnosed with inflammatory bowel disease (IBD) during childhood require transfer to an adult gastroenterologist, in Ontario usually just before their 18th birthday. Pediatric onset IBD is a complex phenotype with demonstrated noncompliance risk that may require targeted measures to optimize health care outcomes in the adult care(More)
Determinants of Intestinal Permeability in Healthy First Degree Relatives of Crohn’s Disease Patients, W. Turpin, D. Kevans, K. Shestopaloff, M. Smith, D. Guttman, M. Silverberg, W. Xu, A. Paterson, and K. Croitoru University of Toronto, Toronto, ON, Canada Mount Sinai Hospital, Toronto, ON, Canada Dalla Lana School of Public Health, Toronto, ON, Canada(More)