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The bile salt excretory pump (BSEP, ABCb11) is critical for ATP-dependent transport of bile acids across the hepatocyte canalicular membrane and for generation of bile acid-dependent bile secretion. Recent studies have demonstrated that the expression of this transporter is sensitive to the flux of bile acids through the hepatocyte, possibly at the level of(More)
BACKGROUND & AIMS The mechanisms by which mutations in the familial intrahepatic cholestasis-1 gene cause Byler's disease (progressive familial intrahepatic cholestasis type 1) are unknown. METHODS Interactions among the apical sodium-dependent bile acid transporter, the farnesoid X receptor (FXR), and familial intrahepatic cholestasis-1 were studied in(More)
Ochratoxin A was administered orally at a dose level of 6 mg/kg/day for eight weeks to rats. Studies on the intestinal cellular macromolecules, activities of membrane bound enzymes and in vivo absorption of 14C-glucose and 14C-glycine exhibited significant alterations. The observed reduction in the absorption of these nutrients during ochratoxin A toxicosis(More)
Bile formation depends on the active secretion of bile salts and other biliary constituents by specific transporters. Recently two major transporters that contribute to bile formation, the bile salt export pump (Bsep) and multidrug resistance protein-2 (Mrp2), have been cloned. The goal of the present study was to define the expression of Bsep and Mrp2(More)
CONTEXT Economic difficulties at the individual level can lead to a number of behavioral problems, including substance abuse and delinquent behaviors. OBJECTIVE To examine the influence of a nationwide adverse economic environment during infancy, specifically, the high unemployment rates during and after the 1980 and 1981-1982 recessions, on rates of(More)
We investigated the role of the orphan nuclear receptor farnesoid X receptor (FXR) in the regulation of cholesterol 7alpha-hydroxylase (CYP7A1), using an in vivo rabbit model, in which the bile acid pool, which includes high affinity ligands for FXR, was eliminated. After 7 days of bile drainage, the enterohepatic bile acid pool, in both New Zealand White(More)
results and conclusions expressed are those of the authors and do not necessarily indicate concurrence by the Bureau of the Census. The results presented in this paper have been screened to ensure that no confidential data are revealed. ACKNOWLEDGEMENTS We thank an anonymous referee for comments that helped us to significantly improve our study. We are(More)