Natania S Field

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We have used Drosophila ovarian follicle stem cells (FSCs) to study how stem cells are regulated by external signals and draw three main conclusions. First, the spatial definition of supportive niche positions for FSCs depends on gradients of Hh and JAK-STAT pathway ligands, which emanate from opposite, distant sites. FSC position may be further refined by(More)
Evidence for the presence in mammalian blood of an estrogen showing phenolic, ketonic, and alcoholic properties was presented in an earlier communication (Werthessen, Baker, and Borci (6)). The biological assay on perfusion experiments indicated that estrogen could be formed from estrone. The estrone used in these studies was dissolved in dilute blood and(More)
During the investigation of the fate of estrone in blood and perfused organs, it was found that@ estrone was converted to a biologically inactive substance (1) , which could no longer be assayed as a 17-ketosteroid (i). Utilization of this latter fact in a study of the conditions under which this con version could occur provided evidence supporting the(More)
The ubiquitin ligase, Itch, is required to prevent autoinflammatory disease in mice and humans. Itch-deficient mice develop lethal pulmonary inflammation characterized by the production of Th2 cytokines (for example, interleukin-4 (IL-4)); however, the contribution of Itch to immune defense against respiratory pathogens has not been determined. We found(More)
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